Metabolism of Sodium Pentosan Polysulphate in Man – Catabolism of Iodinated Derivatives

I R MacGregor; J Dawes; L Paton; D S Pepper; C V Prowse; M Smith

doi:10.1055/s-0038-1661092

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1984; 51(03): 321-325
DOI: 10.1055/s-0038-1661092

Original Article

Schattauer GmbH Stuttgart

Metabolism of Sodium Pentosan Polysulphate in Man – Catabolism of Iodinated Derivatives

Authors

I R MacGregor

¹The Scottish National Blood Transfusion Service Headquarters Unit Laboratory, Edinburgh, Scotland, U.K.
J Dawes

²The MRC/SNBTS Blood Components Assay Group, Edinburgh, Scotland, U.K.
L Paton

³The S-E Scotland Blood Transfusion Service, Royal Infirmary, Edinburgh, Scotland, U.K.
D S Pepper

¹The Scottish National Blood Transfusion Service Headquarters Unit Laboratory, Edinburgh, Scotland, U.K.
C V Prowse

³The S-E Scotland Blood Transfusion Service, Royal Infirmary, Edinburgh, Scotland, U.K.
M Smith

⁴The Department of Medical Physics and Medical Engineering, Royal Infirmary, Edinburgh, Scotland, U.K.

Abstract

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Summary

An iodinated derivative of the heparin analogue SP54 has been prepared and used in conjunction with unlabelled SP54 to study the catabolism and organ distribution of this potential antithrombotic agent in healthy human volunteers. As observed previously with ¹²⁵I-heparin, we found that the ¹²⁵I-SP54 was rapidly cleared from the circulation, returning later in a desulphated form. Organ distribution studies with ¹²³I-SP54 suggested that the liver and spleen were major sites of desulphation. Gel filtration and Polybrene binding showed the presence of sulphated macromolecular SP54 and desulphated macromolecular and depolymerised SP54 in post-injection urines. No depolymerised material was present in plasma suggesting depolymerisation occurs in the kidney.

Keywords

Heparin analogue - SP54 - Metabolism - Iodinated derivatives - Organ distribution

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References

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