L-Asparaginase Lowers Protein C Antigen

• References

• 1 Priest JR, Ramsay NK C, Steinherz PG. et al. A syndrome of thrombosis and hemorrhage complicating L-asparaginase therapy for childhood acute lymphoblastic leukemia. J Pediatr 1982; 100: 984-989
• 2 Pitney WR, Phadke KP, Dean S. Antithrombin III deficiency during asparaginase therapy. Lancet 1980; 1: 493-494
• 3 Barbui T, Rodeghiero F, Meli S, Dini E. Fatal pulmonary embolism and antithrombin III deficiency in adult lymphoblastic leukemia during L-asparaginase therapy. Acta Haematol 1983; 69: 188-191
• 4 Bauer KA, Teitel JM, Rosenberg RD. L-asparaginase induced antithrombin III deficiency: evidence against the production of a hypercoagulable state. Thromb Res 1983; 29: 437-442
• 5 Mannucci PM, Viganò S. Deficiencies of Protein C, an inhibitor of blood coagulation. Lancet 1982; 2: 463-467