Examination of Certain Coagulation Factors in Menstrual Fluid from Women with Normal Blood Loss

S A Cederholm-Williams; Margaret C P Rees; A C Turnbull

doi:10.1055/s-0038-1661182

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1984; 52(03): 224-225
DOI: 10.1055/s-0038-1661182

Original Article

Schattauer GmbH Stuttgart

Examination of Certain Coagulation Factors in Menstrual Fluid from Women with Normal Blood Loss

S A Cederholm-Williams

The Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford, U.K.

,

Margaret C P Rees

The Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford, U.K.

,

A C Turnbull

The Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford, U.K.

› Institutsangaben

Abstract

als PDF herunterladen

Summary

Examination of coagulation factors in menstrual fluid collected from women with normal menstrual blood less (<80 ml) showed the absence of thrombin generating enzymes. Factor X, prothrombin and free thrombin were absent from menstrual fluid. No difference was found between days 1 and 2 of menstruation. Thus activation of coagulation enzymes occurs during normal menstruation though the menstrual blood is characteristically fluid.

Key words

Menstrual blood - Coagulation

PDF (111 kb)

Referenzen

References
1 Quick AJ. Menstruation in hereditary bleeding disorders. Obstet Gynecol 1966; 28: 37-48
2 Nilsson L, Rybo G. Treatment of menorrhagia with an antifibrinolytic agent, tranexamic acid (AMCA). Acta Obstet Gynecol Scand 1967; 46: 572-580
3 Skipetrov VP. The role of tissue factors of the endometrium in noncoagulability of the uterine blood. Exerpta Medica 1966; 10: 764
4 Rybo G. Plasminogen activators in the endometrium. Acta Obstet Gynecol Scand 1966; 45: 429-450
5 Hahn L, Rybo G. Fibrinogen-fibrin degradation products in menstrual blood from women with normal and excessive menstrual blood losses. Acta Obstet Gynecol Scand 1975; 54: 119-127
6 Beller FK. Observations on the clotting of menstrual blood and clot formation. Am J Obstet Gynaecol 1971; 3: 535-546
7 Christiaens GC M L, Sixma JJ, Haspels AA. Fibrin and platelets in menstrual discharge before and after the insertion of an intrauterine device. Am J Obstet Gynecol 1981; 140: 793-798
8 Sheppard BL, Dockeray CJ, Bonnar J. An ultrastructural study of menstrual blood in normal menstruation and dysfunctional uterine bleeding. Br J Obstet Gynaecol 1983; 90: 259-265
9 Christiaens GC M L, Sixma JJ, Haspels AA. Morphology of haemostasis in menstrual endometrium. Br J Obstet Gynaecol 1981; 87: 425-439
10 Lijnen HR, Collen D, Verstraete M. Synthetic substrates in clinical blood coagulation assays. Developments in Haematology. Martinus Nijhoff Publishers; The Hague: 1980. 1 1-114
11 Hallberg L, Hogdahl AM, Nilsson L, Rybo G. Menstrual blood loss - a population study. Acta Obstet Gynecol Scand 1966; 45: 320-351
12 Hallberg L, Nilsson L. Determination of menstrual blood loss. Scand J Clin Lab Invest 1964; 16: 244-248
13 Cederholm-Williams SA. Automated assay of antithrombins. Annal Clin Biochem 1980; 17: 183-184
14 Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965; 2: 235-240
15 Starkey PM. α-2-macroglobulin: a review. In: Collen D, Wiman B, Verstraete M. (Eds) The physiological inhibitors of coagulation of fibrinolysis. Elsevier/North Holland; Amsterdam: 1979. pp l-11