Summary
The ratio of fibrinolytic to fibrinogenolytic effect of recombinant human tissue-type
plasminogen activator was investigated at several concentrations in an in vitro system consisting of 125I-fibrin labeled autologous plasma clots immersed in the plasma of several different
primate species. A concentration-dependent fibrinolysis was obtained in each case;
however, the degree of fibrinolysis differed markedly from one primate species to
the other. At a concentration of 30 IU/ml (300 ng/ml) of recombinant tissue-type plasminogen
activator nearly complete thrombolysis was achieved within 4 hr in human plasma, in
the chimpanzee, in the cynomolgus macaque, in the bonnet macaque and in the rhesus
macaque. The common baboon, the olive baboon and the squirrel monkey were rather resistant
to thrombolysis. In all species the thrombolysis achieved was not associated with
fibrinogenolysis nor with significant decreases in plasminogen or α2-antiplasmin.
Key words
Recombinant tissue-type plasminogen activator - Fibrinolysis - Primates
