High Levels of Plasma Protein C in Nephrotic Syndrome

Summary

In patients with severe nephrotic syndrome determinations of plasma protein C : Ag levels (8 patients: 5 adults, 3 children) and protein C activity (3 out of 8 patients) revealed significantly elevated plasma protein C concentrations. Furthermore we observed a significant inverse correlation of protein C : Ag to AT III : Ag levels. No protein C : Ag could be detected in the urine of two patients studied. We conclude from our data, that changes of plasma protein C do not contribute to the high thrombotic tendency in nephrotic syndrome.

Key words

Protein C - Nephrotic syndrome - AT III - Coagulation inhibitors in patients with nephrotic syndrome

• References

• 1 Kaufmann HR, Graeff Jde, Brutei Gde la Riviere, Es Lvan. Unilateral vein thrombosis and nephrotic syndrome. Am J Med 1976; 60: 1048-1054
• 2 Thaler E, Baizar E, Kopsa H, Pinggera WF. Acquired antithrombin III deficiency in patients with glomerular proteinuria. Hemostasis 1978; 7: 257-272
• 3 Kaufmann HR, Veitkamp JJ, van Tilburg H, van Es L. Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. Am J Med 1978; 65: 607-613
• 4 Boneu B, Bouissou F, Abbai M, Sié P, Caranobe C, Barthe P. Comparison of progressive antithrombin activity and the concentration of three thrombin inhibitors in nephrotic syndrome. Thromb Haemostas 1981; 46: 623-625
• 5 Griffin NH, Evatt B, Zimmermann TS, Kleiss AJ, Widemann C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370-1373
• 6 Bertina RM, Broekmans AW, van der Linden IK, Mertens K. Protein C deficiency in a Dutch family with thrombotic disease. Thromb Haemostas 1982; 48: 1-5
• 7 Pabinger-Fasching I, Bertina RM, Lechner K, Niessner H, Korninger Ch. Protein C deficiency in two Austrian families. Thromb Haemostas 1983; 50: 810-813
• 8 Kisiel W. Human protein C. Isolation, characterisation and mechanism of activation by thrombin J Clin Invest 1979; 64: 761-769
• 9 Francis BR, Patch MJ. A functional assay for protein C in human plasma. Thromb Res 1983; 32: 605-613
• 10 Kendall GA, Lohmann CR, Dossetor JB. Nephrotic syndrome, a hypercoagulable state. Arch Intern Med 1971; 127: 1021-1027
• 11 Girot RF, Jaubert F, Leon M, Bellon B, Aiach M, Josso F, Lepelletier O, Beguin S, Monnet JP. Albumin, fibrinogen, prothrombin and antithrombin III variations in blood, urines and liver in rat nephrotic syndrome (Heymann nephritis). Thromb Haemostas 1983; 49: 13-17
• 12 Stenflo J, Femlund P, Egen W, Roapston F. Vitamin K dependent modification of glutamic acid residues in prothrombin. Proc Natl Acad Sri USA 1974; 71: 2730-2735
• 13 Brenner MB, Bohrer PM, Baylis Ch, Deen WM. Determination of glomerular permselectivity: Insights derived from observations in vivo. Kidney Int 1977; 12: 229-273