Thromb Haemost 1986; 55(01): 002-005
DOI: 10.1055/s-0038-1661434
Original Article
Schattauer GmbH Stuttgart

Urine Beta-Thromboglobulin Concentration or Beta-Thromboglobulin/Creatinine Ratio in Single Voided Urine Samples Cannot Be Reliably Used to Estimate Quantitative Beta-Thromboglobulin Excretion

V Musumeci
The Servizio di Chimica Clinica, Universita Cattolica del Sacro Cuore, Roma, Italy
,
S Rosa
The Servizio di Chimica Clinica, Universita Cattolica del Sacro Cuore, Roma, Italy
,
A Caruso
The Servizio di Chimica Clinica, Universita Cattolica del Sacro Cuore, Roma, Italy
,
B Zappacosta
*   The Istituto di Patologia Speciale Medica and Istituto di Fisiologia Umana, Italy
,
F Tutinelli
The Servizio di Chimica Clinica, Universita Cattolica del Sacro Cuore, Roma, Italy
,
C Zuppi
*   The Istituto di Patologia Speciale Medica and Istituto di Fisiologia Umana, Italy
› Author Affiliations
Further Information

Publication History

Received 12 June 1985

Accepted 13 August 1985

Publication Date:
19 July 2018 (online)

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Summary

Different procedures are currently used in the urine beta-thromboglobulin (BTG) assay. We investigated the reliability of limited urine collections and of different expressions of urine BTG results (concentration, urine BTG/creatinine ratio) for the measurement of hourly or daily BTG excretion rates. BTG was measured by a sensitive RIA method in various urine collections of normal subjects (n.80) and patients (n.120) with miscellaneous diseases where an enhanced in-vivo platelet activation could be expected. The BTG concentration in a 6-hour urine collection appeared to change in relation to the urine flow rate (r = -0.53 in normals, r = 0.27 in patients, p <0.01) and urine osmolality (r = 0.46 in normals, r = 0.31 in patients, p <0.01). In both normals and patients not a very good correlation was observed between the urine BTG/creatinine ratio and the BTG excretion rate (r = 0.54 and r = 0.48; p <0.001, respectively). Variable coefficients of correlation (r = 0.83-0.34) were observed between the BTG excretion rate of single voidings of the morning, afternoon-evening and night and the daily BTG excretion both in normals and patients. Reliable measurements of the BTG in urine should be expressed as the hourly excretion rate in a given period of the day for limited urine collections or as the daily excretion for 24-hour urine collections.