Thromb Haemost 1986; 55(01): 034-036
DOI: 10.1055/s-0038-1661441
Original Article
Schattauer GmbH Stuttgart

Effects of Arginine Vasopressin (AVP) Infusions on Circulating Concentrations of Platelet AVP, Factor VIII: C and von Willebrand Factor

S S Nussey
The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
,
D H Bevan
The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
,
V T Y Ang
The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
,
J S Jenkins
The Departments of Medicine and Haematology, St. George’s Hospital Medical School, London, UK
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Weitere Informationen

Publikationsverlauf

Received 25. Juli 1985

Accepted 11. Oktober 1985

Publikationsdatum:
19. Juli 2018 (online)

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Summary

To study the possible role of arginine vasopressin (AVP) in the control of haemostasis AVP infusions at 3 doses (0.1, 0.2 and 0.3 mU/kg/min) were performed in 6 male volunteers. Both plasma and platelet AVP concentrations rose in a dose-related manner. At doses of 0.2 and 0.3 mU/kg/min there was an increase in the plasma concentrations of both plasma Factor VIII and von Willebrand factor. The data support the hypothesis that AVP, by interacting with platelets and stimulating factor VIII and von Willebrand factor release, plays a role in the control of haemostasis.