Failure of L - Asparaginase to Decrease Protein C - A Possible Rebound Phenomenon

• References

• 1 Barbui T, Finazzi G, Viganò S, Mannucci PM. L-Asparaginase lowers protein C antigen. Thromb Haemostas 1984; 52: 216
• 2 Priest JR, Ramsay NK C, Steinherz PG et al. A syndrome of thrombosis and hemorrhage complicating L-Asparaginase therapy for childhood acute lymphoblastic leukemia. J Pediatr 1982; 100: 984-989
• 3 Cappellato MG, Rosolen A, Zanesco L, Girolami A. Clotting complications of L-Asparaginase therapy in children with ALL. Letter to the Editors. Blut 1986; 52: 377-378
• 4 Pitney WR, Phadke KP, Dean S. Antithrombin III deficiency during asparaginase therapy. Lancet 1980; 1: 493-494
• 5 Vellenga E, Broekmans AW, Kluft C. Thrombotic complications during L-Asparaginase related to Protein C deficiency. Thromb Haemostas 1985; 53: 443
• 6 Dal Bo Zanon R, Fornasiero L, Boscaro M, Cappellato G, Fabris F, Girolami A. Increased factor VIII associated activities in Cushing’s syndrome: a probable hypercoagulable state. Thromb Haemostas 1982; 47: 116-117