Geburtshilfe Frauenheilkd 2018; 78(10): 178-179
DOI: 10.1055/s-0038-1671292
Freitag, 02.11.2018
Endokrinologie und Reproduktionsmedizin II
Georg Thieme Verlag KG Stuttgart · New York

Rheumatic autoimmune diseases as a risk factor for primary ovarian failure

M Henes
1  Department für Frauengesundheit, Universitätsklinikum Tübingen, Tübingen, Deutschland
B Grossmann
2  Universität Tübingen, Tübingen, Deutschland
K Rall
1  Department für Frauengesundheit, Universitätsklinikum Tübingen, Tübingen, Deutschland
J Henes
3  Zentrum für Interdisziplinäre Klinische Immunologie, Rheumatologie und Autoimmunerkrankungen (INDIRA), Tübingen, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
20 September 2018 (online)



The objective of this study was to investigate the relation between premature ovarian failure (POF) and autoimmune diseases (AIDs).


From 2009 – 2017 52 consecutive patients with POF, aged 18 – 40 years, were included in this interdisciplinary, prospective study and screened for underlying AIDs by a rheumatologist via medical history, examination and laboratory tests.


Of all 52 patients with a median age of 31, 40.4% had at least one confirmed AID, including mostly Hashimoto's disease (32.7%), but also systemic lupus erythematosus, rheumatoid arthritis, psoriasis (3.8% each), Crohn's disease and celiac disease (1.9% each). AIDs were associated with a poor infertility treatment-outcome, due to multifactorial reasons.


We found a high prevalence of AIDs in patients with POF. Screening for AID should therefore be offered to every POF patient.