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Rheumatic autoimmune diseases as a risk factor for primary ovarian failure
20 September 2018 (online)
The objective of this study was to investigate the relation between premature ovarian failure (POF) and autoimmune diseases (AIDs).
From 2009 – 2017 52 consecutive patients with POF, aged 18 – 40 years, were included in this interdisciplinary, prospective study and screened for underlying AIDs by a rheumatologist via medical history, examination and laboratory tests.
Of all 52 patients with a median age of 31, 40.4% had at least one confirmed AID, including mostly Hashimoto's disease (32.7%), but also systemic lupus erythematosus, rheumatoid arthritis, psoriasis (3.8% each), Crohn's disease and celiac disease (1.9% each). AIDs were associated with a poor infertility treatment-outcome, due to multifactorial reasons.
We found a high prevalence of AIDs in patients with POF. Screening for AID should therefore be offered to every POF patient.