Geburtshilfe Frauenheilkd 2018; 78(10): 193
DOI: 10.1055/s-0038-1671338
Poster
Freitag, 02.11.2018
Gynäkologische Onkologie VI
Georg Thieme Verlag KG Stuttgart · New York

Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: A prospective study

A Soliman
1  Fakultät für Medizin und Gesundheitswissenschaften Carl von Ossietzky Universität Oldenburg, Universitätsklinik für Gynäkologie und Geburtshilfe, Klinikum Oldenburg AöR, Oldenburg, Deutschland
,
A Elzarka
2  University of Alexandria, Faculty of Medicine, Obstetrics and Gynecology, Alexandria, Ägypten
,
E Malik
1  Fakultät für Medizin und Gesundheitswissenschaften Carl von Ossietzky Universität Oldenburg, Universitätsklinik für Gynäkologie und Geburtshilfe, Klinikum Oldenburg AöR, Oldenburg, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
20 September 2018 (online)

 

Objective:

A numerical score, the Peritoneal Cancer Index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival.

Methods:

This was a prospective cohort study. Patients with primary serous EOC at FIGO stages IIIB or higher were included. Patients with FIGO stage IVB as well as those assigned to receive neoadjuvant treatment were excluded from the study. The PCI was obtained and registered intraoperatively.

Results:

In the study period we recruited 96 patients with serous EOC stage IIIB – IVA. A PCI score cut-off value of 13 was calculated using a receiver operator characteristic (ROC) curve, above which worse survival is expected (AUC 0.641, 95% CI 0.517 – 0.765, sensitivity and specificity 80.6%, 45%, respectively, p = 0.05). A multivariate analysis determined that suboptimal surgical cytoreduction was the only independent predictive factor for recurrence (OR 7.548, 95% CI 1.473 – 38.675, p = 0.015). A multivariate analysis determined that only suboptimal surgical cytoreduction (HR 2.33, 95% CI 0.616 – 8.795, p = 0.005), but not PCI score > 13 (HR 1.289, 95% CI 0.329 – 5.046, p = 0.716), was an independent predictive factor for death.

Conclusions:

We conclude from this study that the PCI score is a reliable tool helping to assess the extent of disease in advanced serous EOC and may help predicting complete surgical cytoreduction but cannot qualify as a predictor of survival.