Geburtshilfe Frauenheilkd 2018; 78(10): 202
DOI: 10.1055/s-0038-1671365
Poster
Freitag, 02.11.2018
Gynäkologische Onkologie VIII
Georg Thieme Verlag KG Stuttgart · New York

Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival.

A Ignatov
1  Universitätsfrauenklinik Magdeburg, Magdeburg, Deutschland
,
T Ignatov
1  Universitätsfrauenklinik Magdeburg, Magdeburg, Deutschland
,
S Costa
1  Universitätsfrauenklinik Magdeburg, Magdeburg, Deutschland
,
H Eggemann
1  Universitätsfrauenklinik Magdeburg, Magdeburg, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
20 September 2018 (online)

 

Background:

Oophorectomy is generally performed in patients with endometrial cancer despite the rate of ovarian metastasis being relatively low.

Patients and methods:

A multicenter retrospective registry-based study was performed in 2329 patients with endometrial cancer. The outcome measures were the incidence of ovarian metastasis and the impact on overall survival.

Results:

Median follow-up was performed at 84 months. A total of 2158 women were eligible for analysis, of which 131 (6.1%) had ovarian metastasis. Women with ovarian metastasis were more likely to have > 50% myometrial invasion, undifferentiated nonendometrioid tumors, and lymph and vascular space invasion. The presence of < 50% myometrial invasion, endometrioid histology, well-differentiated cancer, and negative lymph and vascular space invasion were associated with a very low rate (0.5%) of ovarian metastasis. Notably, after matching for tumor histology and grade, myometrial invasion, and lymph and vascular space invasion, ovarian metastasis was not associated with a reduced median overall survival.

Conclusions:

Ovarian preservation should be offered to premenopausal women with endometrial cancer in whom myometrial invasion is less than 50%, the histological type is endometrioid and well-differentiated, and lymph and vascular space invasion is not involved.