CC BY-NC-ND 4.0 · Journal of Morphological Sciences 2018; 35(04): 203-206
DOI: 10.1055/s-0038-1675361
Review Article
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Perinatal Protein Undernutrition and Cardiovascular System: A Systematic Review

José Emerson Xavier
1   Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Erivaldo Alves Antonio
1   Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Lisiane dos Santos Oliveira
2   Department of Nursery, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, PE, Brazil
,
Sandra Lopes de Souza
3   Departament of Anatomy, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brasil
,
Juliana Pinto de Medeiros
1   Department of Histology and Embryology, Centro de Biociências, Universidade Federal de Pernambuco, Recife, PE, Brazil
,
Lavínia Calmon Lima
4   Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil
,
Carlos Alberto de Carvalho Fraga
4   Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil
,
Rafael Danyllo da Silva Miguel
4   Department of Medicine, Universidade Federal de Alagoas, Arapiraca, AL, Brazil
› Author Affiliations
Further Information

Publication History

29 August 2017

06 September 2018

Publication Date:
31 October 2018 (online)

Abstract

The present study is a systematic review of the literature that aimed to characterize the profile in animal models used to study perinatal protein malnutrition correlating with the cardiovascular system and the implications of malnutrition to the heart. Therefore, an extensive search was conducted in the PubMed, BVS, and SciELO databases, using combinations of the descriptors protein malnutrition, pregnancy, heart, lactation, and cardiovascular system. A total of 247 articles were found, but after excluding duplicities and applying the inclusion/exclusion criteria, only 12 papers remained. The analysis of the results shows that the diet used in the studies has a protein content of between 17 and 22% for the control animals, and of between 0 and 9% for the animals submitted to perinatal protein malnutrition. The main morphofunctional changes observed in the cardiovascular system are related to high blood pressure, increased apoptosis of cardiomyocytes, and reduction in the absolute size of the heart, among other ultrastructural and molecular changes.

 
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