CC BY 4.0 · TH Open 2018; 02(04): e373-e386
DOI: 10.1055/s-0038-1675577
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Cancer-Associated Thrombosis: Beyond Clinical Practice Guidelines—A Multidisciplinary (SEMI–SEOM–SETH) Expert Consensus

Vanessa Pachón
1   Department of Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain
Javier Trujillo-Santos
2   Department of Internal Medicine, Hospital Universitario Santa Lucía, Cartagena, Spain
Pere Domènech
3   Thrombosis and Haemostasis Unit, Hospital Universitario Bellvitge, L'Hospitalet de Llobregat, Catalonia, Spain
Enrique Gallardo
4   Department of Oncology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain
Carmen Font
5   Department of Medical Oncology, Hospital Clinic, Barcelona, Spain
José Ramón González-Porras
6   Hematology Service, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain
Pedro Pérez-Segura
7   Department of Oncology, Hospital Clínico San Carlos, Madrid, Spain
Ana Maestre
8   Department of Internal Medicine, Hospital del Vinalopó, Elche, Spain
José Mateo
9   Hematology Service, Hospital Santa Creu i Sant Pau, Barcelona, Spain
Andrés Muñoz
10   Department of Oncology, Hospital Universitario Gregorio Marañón, Madrid, Spain
María Luisa Peris
11   Department of Internal Medicine, Hospital Provincial de Castellón, Castellón, Spain
Ramón Lecumberri
12   Hematology Service, Clínica Universidad de Navarra, IDISNA, CIBER-CV, Pamplona, Spain
› Author Affiliations
Funding This work has been performed with an unrestricted grant from Aspen, Leo-Pharma, Laboratorios Farmacéuticos Rovi, and Sanofi.
Further Information

Publication History

12 April 2018

17 September 2018

Publication Date:
05 November 2018 (online)


Despite the growing interest and improved knowledge about venous thromboembolism in cancer patients in the last years, there are still many unsolved issues. Due to the limitations of the available literature, evidence-based clinical practice guidelines are not able to give solid recommendations for challenging scenarios often present in the setting of cancer-associated thrombosis (CAT). A multidisciplinary expert panel from three scientific societies—Spanish Society of Internal Medicine (SEMI), Spanish Society of Medical Oncology (SEOM), and Spanish Society Thrombosis and Haemostasis (SETH)—agreed on 12 controversial questions regarding prevention and management of CAT, which were thoroughly reviewed to provide further guidance. The suggestions presented herein may facilitate clinical decisions in specific complex circumstances, until these can be made leaning on reliable scientific evidence.