Abstract
Objective This study was aimed to describe perinatal outcome of a cohort of pregnant patients
with bone and soft tissue tumors and to compare the current series with our group's
previously reported experience.
Methods Pregnant women diagnosed before and during pregnancy were identified, retrospectively,
for the years 2004 to 2014. Relevant maternal and neonatal data were collected.
Results Forty-eight patients were identified. Ten cases were diagnosed during pregnancy.
Pelvis, abdomen, and extremities were the most common tumor locations. Osteosarcoma,
liposarcoma, and Ewing's sarcoma were the most common histological types and comprise
more than 50% of the cases. Metastases occurred in nine cases. Most of the cases (60%)
were treated surgically during pregnancy and delivery occurred at term. Chemotherapy
was delayed until after delivery. There were no perinatal or infant deaths. Patients
presented with advanced maternal disease in 18% in previous report (1983–2003) versus
40% in present report (2004–2014). Metastases were present in 40% and maternal death
rate was approximately 20% in both cohorts.
Conclusion Pregnant women with bone and soft tissue tumors are candidates for standard surgical
management during pregnancy. Other treatments, such as chemotherapy and radiotherapy
must be evaluated for each woman on a case-by-case basis. Iatrogenic prematurity was
common in our findings.
Keywords
sarcomas - cancer - pregnancy - outcomes - perinatal
