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Neuropediatrics 2019; 50(04): 228-234
DOI: 10.1055/s-0038-1677516
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Monocyte Chemoattractant Protein (MCP)-1 in Rotavirus-Associated White Matter Injury in Newborns

Jung Sook Yeom
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Jae-Young Jo
3   Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
,
Ji Sook Park
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Young-Soo Kim
4   Department of Neurology, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Ju-Young Chung
5   Department of Pediatrics, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
,
Tae-Hee Han
6   Department of Diagnostic Laboratory Medicine, Sanggyepaik Hospital, Inje University College of Medicine, Seoul, Republic of Korea
,
Ji-Hyun Seo
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Eun Sil Park
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Jae-Young Lim
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Hyang-Ok Woo
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Hee-Shang Youn
1   Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
,
Chan-Hoo Park
2   Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea
7   Department of Pediatrics, Changwon Gyeongsang National University Hospital, Changwon, Republic of Korea
› Author Affiliations Funding The biospecimens and data used for this study were provided by the Gyeongsang National University Hospital, a member of the Korea Biobank Network. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science, ICT & Future Planning (grant number 2015-0578).
Further Information

Publication History

18 July 2018

09 December 2018

Publication Date:
02 April 2019 (online)

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Abstract

Recent reports have suggested an association between rotavirus infection and a distinctive pattern of white matter injury (WMI) in neonates with seizures; however, the connection between the two is not fully understood. To evaluate the underlying mechanism, we profiled and compared eight cytokines (IL [interleukin]-1β, IL-6, IL-8, IL-10, IFN-γ [interferon-γ ], MCP-1 [monocyte chemoattractant protein-1], MIP-1β [macrophage inflammatory protein-1β], and TNF-α [tumor necrosis factor-α]) in the cerebrospinal fluid (CSF) of 33 neonates with seizures who had no other well-known causes of seizures and 13 control patients (rotavirus-induced gastroenteritis but without seizures). Among the 33 neonates with seizures, 9 showed WMI and all were infected with rotavirus (R + W + ). Among the 24 patients without WMI, 11 were infected with rotavirus (R + W − ) and 13 were not (R − W − ).Only MCP-1 and MIP-1β were different between the groups. MCP-1 was increased in R+ W+ compared with R + W− (p < 0.01), R − W− (p < 0.01), and control (p = 0.03) patients. MIP-1β was decreased in R + W+ compared with R − W− (p < 0.01) and control (p < 0.01), but not R + W− (p = 0.23) patients. MCP-1 and MIP-1β are C-C chemokines that recruit immune cells to the site of inflammation. Our pilot study suggests MCP-1-mediated monocyte recruitment may be linked with this complication caused by rotavirus.

Keywords

cytokines - neonates - rotavirus - seizure

Supplementary Material

 

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