Nuklearmedizin 2019; 58(02): 187
DOI: 10.1055/s-0039-1683719
Poster
Herz, Lunge und Gefäße
Georg Thieme Verlag KG Stuttgart · New York

Brown adipose tissue activation quantified by positron emission tomography/computed tomography describes pulmonary cachexia in COPD patients

A Frille
1   University Hospital Leipzig, Department of Respiratory Medicine, IFB Adiposity Diseases, Leipzig
,
N Linder
2   University Hospital Leipzig, Department of Diagnostic and Interventional Radiology, IFB Adiposity Diseases, Leipzig
,
H Busse
3   University Hospital Leipzig, Department of Diagnostic and Interventional Radiology, Leipzig
,
KG Steinhoff
4   University Hospital Leipzig, Department of Nuclear Medicine, Leipzig
,
H Wirtz
5   University Hospital Leipzig, Department of Respiratory Medicine, Leipzig
,
HJ Seyfarth
5   University Hospital Leipzig, Department of Respiratory Medicine, Leipzig
,
O Sabri
4   University Hospital Leipzig, Department of Nuclear Medicine, Leipzig
,
S Hesse
6   University Hospital Leipzig, Department of Nuclear Medicine, IFB Adiposity Diseases, Leipzig
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2019 (online)

Also available ateRef
 

Ziel/Aim:

Pulmonary cachexia (PC) is often experienced in patients with progressive chronic obstructive pulmonary disease (COPD). Increased activity of brown adipose tissue (BAT) measured by fluorine-18 deoxyglucose (FDG-) positron emission tomography (PET)/computed tomography (CT) might promote PC and be reflected by both reduced muscle mass and adipose tissue. We aimed to find out whether BAT activity measured by FDG-PET/CT reflects differences in body compositions and severity of chronic lung disease.

Methodik/Methods:

Eighty-six patients with end-stage COPD underwent respiratory workup and an FDG-PET/CT. Mean standardized uptake values (SUVmean) of predefined regions of interest in the nuchal and retroclavicular fat regions were measured. SUVmeanwas normalized to liver uptake and reported as SUV ratio (SUVR). A transversal CT image at the level of the lumbar disc L3/L4 was selected. A click-wise selection of the regions of interest was performed and results were controlled by histogram. Resulting areas are representing total adipose tissue (TAT), including visceral (VAT) and subcutaneous adipose tissue as well as total muscle tissue (TMT). Likewise mean muscle attenuation (MA) was determined. These data were related to each other and to body weight (body mass index [BMI]) and to pulmonary function. Spearman's rank correlation coefficients were calculated.

Ergebnisse/Results:

Higher SUVR in putative BAT regions was significantly associated with lower BMI (r =-0.40), lower VAT (r =-0.57), lower TMT (r =-0.26), and higher MA (r = 0.35). BAT SUVR positively correlated with higher residual volume and total lung capacity (r = 0.26, r = 0.23, respectively).

Schlussfolgerungen/Conclusions:

Higher BAT activity quantified by FDG-PET/CT is associated with both reduced body weight, visceral adipose tissue and muscle mass as well as with severity of COPD in terms of emphysema. BAT activation might therefore describe a cachectic phenotype in end-stage COPD.