Thromb Haemost 2019; 119(06): 894-898
DOI: 10.1055/s-0039-1683932
Coagulation and Fibrinolysis
Georg Thieme Verlag KG Stuttgart · New York

Age-Specific Reference Intervals for PT, aPTT, Fibrinogen and Thrombin Time for Parturient Women

Gao-Ming Zhang
1  Department of Laboratory Medicine, Shuyang People's Hospital, Shuyang Hospital Affiliated to Xuzhou Medical University, Shuyang, Jiangsu, China
,
Wei Zhang
1  Department of Laboratory Medicine, Shuyang People's Hospital, Shuyang Hospital Affiliated to Xuzhou Medical University, Shuyang, Jiangsu, China
,
1  Department of Laboratory Medicine, Shuyang People's Hospital, Shuyang Hospital Affiliated to Xuzhou Medical University, Shuyang, Jiangsu, China
› Author Affiliations
Funding This work was supported by a research grant from the Jiangsu Commission of Health (H2018076).
Further Information

Publication History

06 January 2019

15 February 2019

Publication Date:
01 April 2019 (online)

Abstract

Background Parturient women are healthy individuals who require special consideration. Parturient women are considered to be in a hyper-coagulable state. For example, the fibrinogen (FIB) levels are often higher than the upper limit of normal reference intervals (RIs) in parturient women than in non-parturient healthy individuals (2–4 g/L).

Objective The aim of this study is to establish the RIs of pro-thrombin time (PT), activated partial thromboplastin time (aPTT), FIB levels and thrombin time (TT) for parturient women.

Materials and Methods Blood levels of PT, aPTT, FIB and TT were assayed on an ACL TOP 700 automatic coagulation analyser using plasma samples from 10,472 parturient women. Outlier results were excluded by using Tukey's test. The RIs were calculated by the Clinical and Laboratory Standards Institute C28-A3 guideline.

Results The RIs of PT, aPTT, FIB and TT were 8.7 to 12.1 seconds (8.7–12.2 seconds for 16–20 years old, 8.7–12.1 second for 21–25 years old, 8.6–12.0 second for 26–30 years old, 8.7–12.0 second for 31–35 years old, 8.7–12.6 second for 36–40 years old and 8.8–12.2 second for 41 years old), 22.9 to 42.3 seconds, 1.98 to 5.82 g/L and 9.9 to 16.7 seconds, respectively. PT levels were found to be positively associated with aging.

Conclusion The above-established age-specific RIs, defined by using a large dataset, may assist clinicians in making accurate medical decisions. This was the first study in which the RIs of PT, aPTT, FIB and TT were established for parturient women in different age groups.

Authors' Contributions

Gao-Ming Zhang and Guo-ming Zhang designed the research; Wei Zhang and Guo-Ming Zhnag analysed the data; and Gao-Ming Zhang and Guo-Ming Zhang wrote the manuscript.


Wei Zhang and Guo-Ming Zhang are co-first authors and contributed equally to this work.