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Semin Respir Crit Care Med 2019; 40(02): 194-207
DOI: 10.1055/s-0039-1683995
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pulmonary Complications of Rheumatoid Arthritis

Authors

  • Hamish Farquhar

    1   Department of Allergy, Immunology and Rheumatology, Christchurch Hospital, Christchurch, New Zealand

  • Robert Vassallo

    2   Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota

  • Adrienne L. Edwards   *

    3   Respiratory Department, Christchurch Hospital, Christchurch, New Zealand

  • Eric L. Matteson   *

    1   Department of Allergy, Immunology and Rheumatology, Christchurch Hospital, Christchurch, New Zealand
    4   Division of Rheumatology and Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota
Further Information

Publication History

Publication Date:
28 May 2019 (online)

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Abstract

Rheumatoid arthritis (RA) is a common chronic autoimmune disorder that characteristically causes joint inflammation and damage. In addition, many patients develop extraarticular manifestations which may cause significant comorbidity and premature mortality.

Some respiratory tract involvement of the upper and lower airways and parenchymal disease features are unique to RA, including cricoarytenoid arthritis and RA pulmonary nodulosis, and others, especially the interstitial parenchymal involvement, occur in many other idiopathic and autoimmune diseases. The pathophysiology of lung disease is not well understood. Rheumatoid lung disease may even predate the onset of joint disease, and could be triggered by chronic airway and alveolar epithelial injury. Chronic systemic inflammation and risk factors such as cigarette smoking, infection, host genetics, and immune dysregulation are contributors. Treatment of the respiratory disease is directed at reducing the systemic inflammation of RA. Less well understood is the management of the interstitial lung disease of RA, for which antifibrotic and immune suppressive agents may be helpful. The management of RA-related lung disease is perhaps the major remaining hurdle in reduction of the disease burden related to extraarticular manifestations of this disease.

Keywords

rheumatoid arthritis - airways disease - lung disease - interstitial lung disease - pathology - diagnosis - treatment

* Both the authors contributed equally to this work.