Thorac Cardiovasc Surg 2019; 67(04): 251-256
DOI: 10.1055/s-0039-1685177
Original Cardiovascular
Georg Thieme Verlag KG Stuttgart · New York

Impact of COPD on Outcome in Patients Undergoing Transfemoral versus Transapical TAVI

Markus Mach
1  Department of Cardiovascular Surgery, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular Research, Vienna, Austria
2  Division of Cardiac Surgery, Medical University of Graz, Austria
,
Matthias Koschutnik
1  Department of Cardiovascular Surgery, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular Research, Vienna, Austria
,
Manuel Wilbring
3  Department of Cardiac Surgery, University Heart Center Dresden, Dresden, Germany
,
Bernhard Winkler
1  Department of Cardiovascular Surgery, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular Research, Vienna, Austria
,
Matthias Reinweber
4  Department for Statistical Data Management, Clinical Research Center Vienna, Vienna, Austria
,
Konstantin Alexiou
3  Department of Cardiac Surgery, University Heart Center Dresden, Dresden, Germany
,
Utz Kappert
3  Department of Cardiac Surgery, University Heart Center Dresden, Dresden, Germany
,
Christopher Adlbrecht
5  Fourth Medical Department, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular & Intensive Care Research, Vienna, Austria
,
Georg Delle-Karth
5  Fourth Medical Department, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular & Intensive Care Research, Vienna, Austria
,
Martin Grabenwöger
1  Department of Cardiovascular Surgery, Heart Team Vienna, Hospital Hietzing and the Karl Landsteiner Institute for Cardiovascular Research, Vienna, Austria
6  Sigmund Freud University, Medical Faculty, Vienna, Austria
,
Klaus Ehrhard Matschke
3  Department of Cardiac Surgery, University Heart Center Dresden, Dresden, Germany
› Author Affiliations
Further Information

Publication History

07 September 2018

14 February 2019

Publication Date:
04 April 2019 (online)

Abstract

Objective The purpose of this study was to evaluate the impact of chronic obstructive pulmonary disease (COPD) on clinical outcomes in patients referred for transfemoral (TF) as well as transapical (TA) aortic valve implantation and furthermore to delineate possible advantages of the TF access.

Methods One thousand eight hundred forty-two patients undergoing transcatheter aortic valve implantation (TAVI) at two study centers were included in the present analysis. The outcome was measured and classified according to Valve Academic Research Consortium-II criteria. Kaplan–Meier estimate was used to assess long-term survival.

Results The present analysis suggests that COPD has limited influence on post-procedural outcome after TAVI. Comparing the TF to TA approach, no significant difference on the impact of COPD on clinical outcomes has been found, except for longer post-procedural ventilation times in COPD patients treated via TA access (p < 0.001).

Conclusions COPD in patients referred for TAVI procedure was associated with poorer overall long-term survival, thus characterizing a high-risk population for futile treatment; however, the selection of access did not result in a significant difference in most Valve Academic Research Consortium-II-defined clinical outcomes in COPD patients.

Author Contribution

In accordance with the ICMJE criteria, all listed authors actively contributed to this manuscript by jointly drafting, revising, and approving the publication of this manuscript. While Prof. Matschke, Prof. Grabenwöger, Prof. Kappert, and Prof. Delle-Karth elaborated the concept, design, and methodology of the manuscript, Dr. Mach and Dr. Wilbring conducted the data acquisition and drafted the manuscript. Mag. Reinweber, Dr. Alexiou, Dr. Wilbring, Dr. Adlbrecht, and Dr. Koschutnik contributed immensely by supporting the analysis and interpretation of the collected data. All of the authors agree to be accountable for all aspects of the work.


Disclosure

Dr. Mach has received a research grant from Edwards Lifesciences and Symetis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.


Supplementary Material