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DOI: 10.1055/s-0039-1685612
The Quantum Blue® (Bühlmann Laboratories AG) Rapid Test identifies increased levels of S100A8/A9 in saliva and serum of patients with peritonsillar abscess
Buhlmann Laboratories AG, SwitzerlandIntroduction:
Increased S100A8/A9 (Calprotectin) levels can serve as a biomarker for tonsil-related diseases such as peritonsillarabscess (PTA). The Quantum Blue® (Bühlmann Laboratories AG) Rapid Test was used for determination of calprotectin levels in saliva and serum from patients with PTA in the context of a pilot study.
Methods:
Serum and saliva samples were acquired from patients with PTA prior to an intervention as well as from healthy controls. The Quantum Blue® Rapid Test was used to determine the Calprotectin levels as point-of-care-instrument.
Results:
36 patients with PTA (20 male, 16 female, median age: 33 years, range 10 – 83 years) and 15 healthy controls (6 male, 9 female, median age: 30 years, 26 – 59 years) were included in this pilot study. Significant higher Calprotectin levels could be observed in serum (PTA 5745 +- 827 ng/ml (mean +- SEM) vs. control (780 +- 103 ng/ml, p < 0.001)) and even in saliva of patients with PTA (PTA 25824 +- 5942 ng/ml vs. control 3385 +- 1136 ng/ml, p = 0.002).
Conclusions:
Significantly increased Calprotectin levels could be identified in both serum and saliva of patients with PTA by the Quantum Blue Rapid Test. The rapid test serves as an appropriate point-of-care testing method for determination of Calprotectin levels in cases of PTA. Further studies will now have to prove the potential of the Quantum Blue® Rapid Test as a diagnostic tool for early and reliable identification of a peritonsillar abscess during outpatient management.
Publikationsverlauf
Publikationsdatum:
23. April 2019 (online)
© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
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Stuttgart · New York