CC BY-NC-ND 4.0 · Laryngorhinootologie 2019; 98(S 02): S275-S276
DOI: 10.1055/s-0039-1686101
Poster
Oncology

Frequency and potential factors for the development of oesophageal stenoses after radiotherapy in patients with head and neck cancer

L Zaubitzer
1   Klinik für Hals-Nasen- Ohrenheilkunde UMM, Mannheim
,
N Rotter
2   Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie Universitätsmedizin Mannheim, Mannheim
,
Y Abo-Madyan
3   Klinik für Strahlentherapie und Radioonkologie Universitätsmedizin Mannheim, Mannheim
,
JT Maurer
2   Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie Universitätsmedizin Mannheim, Mannheim
› Author Affiliations
 

Introduction:

Radiotherapy is one treatment modality for head and neck cancer.

One relevant adverse effect of radiotherapy is an hypopharyngeal or oesophageal stenosis. The aim of this study is to assess frequency and potential factors for the development of oesophageal post radiation stenosis.

Methods:

A retrospective observational study of 132 patients (107 male, 25 female, age 62,6 ± 10,8 years) who received radiotherapy due from 2013 to 2016 to a primary diagnosis of an head neck cancer. The appearance of a stenosis, radition dose, other treatment modalities (neck dissection, surgical therapy of the primary, chemotherapy), and tube feeding/PEG during radiotherapy were assessed. A stenosis was defined as the inability to enter the oesophagus with a flexible gastro-oesophagoscope.

Results:

35 (26,52%) patients suffered under dysphagia after radiotherapy, in addition further 21 patients (15,9%) developed stenoses. There was no significant difference in the frequency of stenoses between the groups with and without additional chemotherapy, ND, surgical therapy and tube feeding/PEG. The median dose of radiation for the primary site was 62,5 ± 11,6 Gy, and 55,9 ± 14,2 Gy for the neck. There were no significant differences of the median radiation doses or cancer stage (T, N, M) between the group with and without post-radiation stenosis.

Discussion:

15.8% of the patients with radiotherapy developed a stenosis, irrespective of multiple factors, which is in line with recent studies. A more detailed analysis of the 3D irradiation record seems to be necessary to get more information about the relation between radiotherapy and the development and extent of oesophageal stenosis.



Publication History

Publication Date:
23 April 2019 (online)

© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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