CC BY-NC-ND 4.0 · Laryngorhinootologie 2019; 98(S 02): S329
DOI: 10.1055/s-0039-1686522

Ototoxicity by some Cancer Patients

K Tenev
1   ENT Oncology Dep., KOC Stara Zagora, Stara Zagora, Bulgaria
M Hristova
2   Chemotherapy, KOC Stara Zagora, Stara Zagora, Bulgaria
› Author Affiliations


Cisplatin is common drug for treatment of some malignant tumors. Hearing loss, tinnitus and vertigo are very often side effects by oncology patients who are treated with combinations with other drugs – Antibiotics, Analgetics, Other anticancer drugs, Cardiovascular drugs, Neurologic drugs. Sensoneural Hearing loss – hight frecuency sounds -4000 – 8000 Hz/1/are commonly affected.

Material and methods:

We observed 34 patients/16 female and 18 male/who were treated with Cisplastin combinated with other drugs. We tried to systemize the most common groups of drugs that increase hearing loss in combination with Cisplatin 50 mg/m2 i.v. 1,8 day., Vinorelbin 25 mg/m2 i.v. 1,8,15 day


We recommend to discuss clinical strategy to prevent this side effects, when combinating this therapy with other drugs. We constatated that Ototoxicity/60 db SNHL/increases the side effects when Cisplatin is combined with other medicaments.


Cisplatin is widely used anticancer drug which causes irreversible hearing loss/5/.

Doctors should be familiar with the common side effects of some anticancer drugs they usually use with combination with others ototoxic dugs.

It is very important to discus treatment of Patients presenting for the first time with an otologic symptoms.

Publication History

Publication Date:
23 April 2019 (online)

© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (

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