CC BY-NC-ND 4.0 · Laryngorhinootologie 2019; 98(S 02): S188
DOI: 10.1055/s-0039-1686795
Abstracts
Sleeping Disorders

ADHERE – Registry: Selective upper airway stimulation and its predictors of treatment efficacy

C Heiser
1   Univ. HNO-Klinik, TU r. d. I., München
,
JT Maurer
2   Universitäts-HNO-Klinik Mannheim, Universitätsklinikum Mannheim., Mannheim
,
JU Sommer
3   HELIOS Universitätsklinikum Wupperta, Wuppertal
,
B Hofauer
1   Univ. HNO-Klinik, TU r. d. I., München
,
A Steffen
4   Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Universität zu Lübeck, Lübeck
› Author Affiliations
 

Introduction:

The aim of this registry is to identify clinical predictors of response of upper airway stimulation (UAS) and to record the evaluation of subjective and objective outcomes in an international multicenter registry.

Methods:

Patients, who received an implantation with an UAS (Inspire Upper Airway Stimulation Systems, Inspire Medical Systems, Maple Grove, USA) in Germany and USA were included in the registry. The following data was collected: demographics, history, apnea-hypopnea index (AHI), Epworth Sleepiness Scale (ESS), body mass index (BMI), objective adherence, adverse events, and patient satisfaction measures. Post-hoc univariate and multiple logistic regression analyzes were performed to evaluate factors associated with treatment success (≥50% reduction in AHI to < 20 events/hour).

Results:

Between October 2016 and September 2018, a total of 706 participants from 14 centers were included. The median AHI 12 months after implantation was reduced from 33.5 to 8.0 events/h and the ESS from 11.0 to 6.0. In the post-hoc analyzes, the likelihood of treatment success increased by 4% for every one-year increase in age. For every 1-month increase in BMI, there was a 9% reduced chance of treatment success. In the multivariate model, age persisted as a statistically significant predictor of treatment success. Therapy adherence was 5.6 ± 2.1 hours/night.

Conclusion:

In a large international multicenter registry, UAS is an effective treatment option. Increasing age and low BMI are success predictors of treatment.



Publication History

Publication Date:
23 April 2019 (online)

© 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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