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CC BY-NC-ND 4.0 · Eur J Dent 2019; 13(02): 243-247
DOI: 10.1055/s-0039-1688524
Original Article
Dental Investigation Society

Effects of Addition of Quaternary Ammonium Antimicrobial Compounds into Root Canal Sealers

Mirjana L. Paunovska
1   Department of Pediatric and Preventive Dentistry, Faculty of Dentistry, SS. Cyril and Methodius University, Skopje, Republic of North Macedonia
,
Nichola J. Coleman
2   School of Engineering and Science, University of Greenwich at Medway, Chatham Maritime, Kent, United Kingdom
,
Marija M. Stevanovic
1   Department of Pediatric and Preventive Dentistry, Faculty of Dentistry, SS. Cyril and Methodius University, Skopje, Republic of North Macedonia
,
Aleksandar G. Dimkov
1   Department of Pediatric and Preventive Dentistry, Faculty of Dentistry, SS. Cyril and Methodius University, Skopje, Republic of North Macedonia
,
Dragana Gabric
3   Department of Oral Surgery, School of Dental Medicine, University Hospital Center, University of Zagreb, Zagreb, Croatia
,
Elizabeta S. Gjorgievska
1   Department of Pediatric and Preventive Dentistry, Faculty of Dentistry, SS. Cyril and Methodius University, Skopje, Republic of North Macedonia
› Author Affiliations Funding None.
Further Information

Publication History

Publication Date:
03 September 2019 (online)

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Abstract

Objective The aim of this study is to determine the effect of the addition of benzalkonium chloride and cetylpyridinium chloride in three commercial root canal sealers.

Materials and Methods Three different root canal sealers were used: EndoRez, N2, and Apexit Plus. The samples were prepared by mixing the components according to the manufacturers’ guidelines and adding 2% in weight of the antimicrobials to the newly mixed cement. The paste was placed in molds and stored in an incubator (37°C, 24 h). The samples were then stored in 5-mL distilled water. Samples without antimicrobials served as a control. All samples were tested at 3 time intervals: 1 day, 1 week, and 1 month following their storage in distilled water. The impact of the antimicrobials on the solubility of the sealers, the release of chloride ions (Cl—), and the pH value were examined.

Statistical Analysis Analysis was done using one-way analysis of variance and the post hoc Tukey's honestly significant difference test.

Results Chloride ions are present in storage media with EndoRez, N2, and Apexit Plus samples (without antimicrobials) following all tested storage intervals. The addition of the antimicrobials increased the release of chloride ions. Endodontic cements without addition of antimicrobials show an increase in weight after 1 month. The highest pH value is measured in Apexit Plus samples. The solutions in which N2 samples (with and without addition of antimicrobials) were stored did not have a significant change in their pH, while in the EndoRez solutions, a significant decrease in the pH value after the first week was measured.

Conclusions The addition of antimicrobials might lead to improved characteristics of the root canal sealers.

Keywords

benzalkonium chloride - chloride - pH - root canal sealers - solubility
 

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