A Green, Scalable, One-Minute Synthesis of Benzimidazoles

Vijayaragavan Elumalai; Jørn H. Hansen

doi:10.1055/s-0039-1690797

Synlett, Table of Contents

Synlett 2020; 31(06): 547-552
DOI: 10.1055/s-0039-1690797

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A Green, Scalable, One-Minute Synthesis of Benzimidazoles

Authors

Vijayaragavan Elumalai

UiT The Arctic University of Norway, Department of Chemistry, Chemical Synthesis and Analysis Division, Hansine Hansens veg 54, 9037 Tromsø, Norway Email: jorn.h.hansen@uit.no Email: vijayaragavan.elumalai@uit.no
Jørn H. Hansen∗

Abstract

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Published as part of the ISySyCat2019 Special Issue

Abstract

Herein is reported a substantially improved synthesis of 2-substituted benzimidazoles by condensation of 1,2-diaminoarenes and aldehydes using methanol as the reaction medium. The developed method afforded moderate to excellent yields (33–96%) at ambient temperature, displays high functional group tolerance, is conducted open to air, and requires only one minute reaction time under catalyst- and additive-free conditions. Moreover, the efficient protocol permits scale-up to multi-gram scale synthesis of benzimidazoles and will become a method of choice when constructing such heterocyclic systems.

Key words

benzimidazoles - green synthesis - rapid condensation - heterocyclization - 1,2-diaminoarenes - catalyst-free reactions

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References

References and Notes

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16 2-([1,1'-Biphenyl]-4-yl)-1H-benzo[d]imidazole (3g); Typical Procedure In a 25 mL round-bottomed flask, diamine 1g (100 mg, 0.93 mmol) was dissolved in MeOH (5 mL). To the stirred solution was added aldehyde 2g (169 mg, 0.925 mmol) and it was stirred for 1 min at rt. Then, the reaction was quenched with water (10 mL), diluted with EtOAc (50 mL), and washed with water (30 mL). The water layer was extracted with EtOAc (2 × 30 mL). The organic layers were combined and dried with anhydrous Na₂SO₄. The drying agent was removed by filtration and the solvent was evaporated under reduced pressure. The crude product was further isolated by using flash chromatography (EtOAc/n-pentane, 20:80) to obtain compound 3g as a yellow solid. Yield: 200 mg (80%); R_f = 0.48 (EtOAc/n-pentane, 30:70). ¹H NMR (400 MHz, acetone-d ₆): δ = 8.58 (s, 1 H), 7.99–7.92 (m, 2 H), 7.70–7.64 (m, 2 H), 7.64–7.57 (m, 2 H), 7.36 (dd, J = 8.4, 6.9 Hz, 2 H), 7.31–7.22 (m, 1 H), 7.02 (dd, J = 7.8, 1.4 Hz, 1 H), 6.87 (td, J = 7.6, 1.4 Hz, 1 H), 6.66 (dd, J = 8.0, 1.4 Hz, 1 H), 6.50 (td, J = 7.5, 1.4 Hz, 1 H). ¹³C NMR (101 MHz, acetone-d ₆): δ = 156.6, 144.7, 129.8, 129.7, 128.5, 128.3, 127.8, 127.6, 117.6, 117.5, 115.6. HRMS: m/z [M + H]⁺ calcd for C₁₉H₁₅N₂ ⁺: 271.1230; found: 271.1232.
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19 Gram-Scale Synthesis of 2-(4-Nitrophenyl)-1H-benzo[d]imidazole (3b) In a 250 mL round-bottomed flask, benzene-1,2-diamine 1b (2.00 g, 18.5 mmol) was dissolved in MeOH (50 mL). To the stirred solution was added 4-nitrobenzaldehyde 2b (2.80 g, 18.5 mmol) and it was stirred for 1 min at rt. Then, the reaction was quenched with water (40 mL) and diluted with EtOAc (50 mL). After a while, crystals were formed in the reaction mixture at rt. The crystals were filtered off and dried to obtain compound 3b as dark-brown crystals. Yield: 2.85 g (65%). ¹H NMR (400 MHz, DMSO-d ₆): δ = 8.83 (s, 1 H), 8.40–8.30 (m, 2 H), 8.34–8.22 (m, 2 H), 7.24 (dd, J = 8.0, 1.5 Hz, 1 H), 7.03 (ddd, J = 8.3, 7.2, 1.4 Hz, 1 H), 6.76 (dd, J = 8.1, 1.4 Hz, 1 H), 6.63–6.53 (m, 1 H). ¹³C NMR (101 MHz, DMSO-d ₆): δ = 153.5, 148.3, 144.9, 142.4, 133.9, 129.4, 128.8, 123.9, 117.0, 116.0, 115.1. HRMS: m/z [M – H]^– calcd for C₁₃H₈N₃O₂ ^–: 238.0622; found: 238.0623.

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