Recent Advances in Ruthenium-Catalyzed Carbene/Alkyne Metathesis (CAM) Transformations

Damián Padín; Jesús A. Varela; Carlos Saá

doi:10.1055/s-0039-1690861

Synlett, Inhaltsverzeichnis

Synlett 2020; 31(12): 1147-1157
DOI: 10.1055/s-0039-1690861

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Recent Advances in Ruthenium-Catalyzed Carbene/Alkyne Metathesis (CAM) Transformations

Damián Padín

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain eMail: carlos.saa@usc.es

,

Jesús A. Varela

,

Carlos Saá ∗

› Institutsangaben

Abstract

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Abstract

Carbene intermediates have shown versatile applications in modern synthetic chemistry. Catalytic ruthenium carbene/alkyne metathesis (CAM) with readily available substrates renders an efficient procedure for the in situ generation of ruthenium vinyl carbene intermediates. Here, recent advances in synthetic applications of ruthenium-catalyzed carbene/alkyne metathesis (CAM) are highlighted.

1 Introduction

2 Ruthenium Vinyl Carbenes through Carbene/Alkyne Metathesis (CAM)

3 Nonpolar Transformations of Ruthenium Vinyl Carbenes

4 Polar Transformations of Ruthenium Vinyl Carbenes

4.1 Intramolecular Ruthenium-Catalyzed [1,5]- and [1,6]-Hydride Transfer/Cyclization

4.2 Heterocyclizations of Alkynals and Alkynones

4.3 Heterocyclizations of ortho-(Alkynyloxy)benzylamines

5 DFT Studies on the Stereoselectivity of the CAM Reaction

6 Conclusions

Key words

alkynyl derivatives - carbenes - cyclization - heterocycles - metathesis - vinyl ruthenium carbenes

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Referenzen

References and Notes

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