Abstract
The term “nanotechnology” was coined by Norio Taniguchi in the 1970s to describe the
manipulation of materials at the nano (10−9) scale, and the term “nanomedicine” was put forward by Eric Drexler and Robert Freitas
Jr. in the 1990s to signify the application of nanotechnology in medicine. Nanomedicine
encompasses a variety of systems including nanoparticles, nanofibers, surface nano-patterning,
nanoporous matrices, and nanoscale coatings. Of these, nanoparticle-based applications
in drug formulations and delivery have emerged as the most utilized nanomedicine system.
This review aims to present a comprehensive assessment of nanomedicine approaches
in vascular diseases, emphasizing particle designs, therapeutic effects, and current
state-of-the-art. The expected advantages of utilizing nanoparticles for drug delivery
stem from the particle's ability to (1) protect the drug from plasma-induced deactivation;
(2) optimize drug pharmacokinetics and biodistribution; (3) enhance drug delivery
to the disease site via passive and active mechanisms; (4) modulate drug release mechanisms
via diffusion, degradation, and other unique stimuli-triggered processes; and (5)
biodegrade or get eliminated safely from the body. Several nanoparticle systems encapsulating
a variety of payloads have shown these advantages in vascular drug delivery applications
in preclinical evaluation. At the same time, new challenges have emerged regarding
discrepancy between expected and actual fate of nanoparticles in vivo, manufacturing
barriers of complex nanoparticle designs, and issues of toxicity and immune response,
which have limited successful clinical translation of vascular nanomedicine systems.
In this context, this review will discuss challenges and opportunities to advance
the field of vascular nanomedicine.
Keywords
nanomedicine - vascular - targeting - drug delivery - animal models
