CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2019; 08(02): 123-126
DOI: 10.1055/s-0039-1696069
Short Communication
Neurological Surgeons' Society of India

Primary Cerebral Plasmacytoma: A Rare Case Report with Review of Literature

Arun Kumar
1  Department of Neurosurgery, The Neurocity Hospital, Varanasi, Uttar Pradesh
Biswaranjan Nayak
2  Department of Neurosurgery, AMRI Hospital, Bhubaneswar, Odisha
Balappa Holeppagol Krishnamurthy
3  Department of Neurosurgery, Max Hospital, Patparganj, Delhi
Sushant Kumar Patro
4  Department of Neurosurgery, Ispat General Hospital, Rourkela, Odisha
Prafulla Kumar Sahoo
5  Department of Neurosurgery, Apollo Hospital, Bhubaneswar, Odisha, India
› Author Affiliations
Funding No financial support of any kind from anybody for this study was received.
Further Information

Publication History

Received: 14 June 2018

Accepted after revision: 13 August 2018

Publication Date:
27 August 2019 (online)



Solitary craniocerebral plasmacytoma is the least common form of extramedullary solitary plasmacytoma (SP). Cerebral SP is very rare. The world literature counts only seven intracranial cases. The authors report a case of cerebral tumor of SP in a 52-year-old female who presented to a hospital with headache and difficulty in walking for 6 months. Contrast-enhanced computed tomography (CECT) brain showed left occipital intracranial space occupying lesions (ICSOL) of size 26 mm × 14 mm adjacent to superior sagittal sinus with disproportionate perilesional edema and midline shift toward the right. She underwent gross total tumor excision with left fronto-temporo-parietal decompressive craniectomy. Microscopic sections showed highly cellular tumor infiltrating white matter and gray matter. Histopathology revealed plasmacytoma. These plasma cells were seen infiltrating the adjoining brain parenchyma. Immunohistochemistry study showed the following pattern of antigens: most of the cells were negative to CD138 antibody, and majority of cells were positive (++ to +++) to CD56 antibody, more groups of cells were positive to lambda antibody than KAPPA. Bone marrow biopsy showed only 1% polyclonal plasma cells. Whole body bone scan showed no evidence of any osteoblastic skeletal metastasis. The patient recovered well, and cranioplasty was done after 6 weeks.

Conclusion Cerebral SP is rarely found in clinical practice and if diagnosed properly can save patients life. This case report would definitely address many unexplored facts about cerebral SP and set milestone in the field of clinical research.