CC BY-NC-ND 4.0 · Indian Journal of Neurosurgery 2019; 08(02): 091-093
DOI: 10.1055/s-0039-1697529
Neurological Surgeons' Society of India

Transition from Microscopic to Endoscopic Pituitary Surgery

Abrar Ahad Wani
1  Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
Mohsin Bhat
1  Department of Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
› Author Affiliations
Further Information

Publication History

Publication Date:
20 September 2019 (online)


The microscopic transnasal tumor surgery (TNTS) has stood the test of time since its inception in 1960; however, the advent of the endoscopic nasal pituitary surgery (EPS) has made inroads in this particular field with its myriad benefits. Both TNTS and EPS procedures are effective tools in tackling pituitary tumors.[1] The ardent supporters of TNTS promote the benefits of maintaining stereoscopic vision, instrument mobility, control of bleeding effectively, retraction of the edematous nasal tissues, and quick access to the sella. On the other hand, the transition to the EPS procedure is happening worldwide, clearly on account of its advantages, which include a wide panoramic view, improved illumination, ability to look around the anatomical corners using an angled tip, and extended approach to the paraseller tumors.[1] Instrumental maneuverability during the endoscopic procedures has been alleviated with the introduction of newer endoscopic specific instruments, and high-definition 3D endoscopic system may resolve issues pertaining to stereoscopic resolution.

Meta-analyses reveal a clear advantage of EPS over the TNTS procedure in relation to the locally invasive tumor with parasellar extension; its benefits also include more effective resection and good endocrinological outcome.[2] [3] For tumors invading the cavernous sinus, higher resection rates have been observed, with the endoscope depicting a clear advantage of the panoramic and the angled views of the cavernous sinus medial wall.[4] [5] EPS is considered a valid option in treating recurrent forms of adenoma. Wide exposure of the sella is especially ensured, keeping in mind the limited exposure of the previous microscopic surgical procedures, which was responsible for incomplete tumor resection. Nasal morbidities such as sinusitis, anosmia, epistaxis, nasal congestion, and septal perforation are comparatively lesser in amount in the endoscopic nasal surgery.[1] A comfortable postoperative course is provided by way of the following:

  1. Lesser mucosal detachment

  2. Absence of sub-labial incision

  3. Absence of routine nasal packing

These result in the reduction of the postoperative pain and ensure a quick recovery and short hospital stay.[1]

Despite the wider exposure and dissection, and the attendant higher risk of the intra-operative CSF leak, the incidence of the postoperative leak in the EPS is equivalent to the microscopic surgery in the recent literature.[1] The risk of permanent diabetes insipidus is between 0.7 and 8.5%.[6] Injury to the carotid artery is a rare but potentially life-threatening complication.[7] Thus, in general, the surgical complication rate of the endoscopic approach is equal to that of the microscopic approach. Endoscopic nasal surgery is cost effective in comparison to its microscopic counterpart. The learning curve may deter some microscopically trained neurosurgeons from embracing the endoscopic approach, because of an unwillingness on their part to accept the complications during the procedure. This can be overcome by attending workshops concerning endoscopic nasal and paranasal anatomy, endoscopic surgery, and then gradually moving from endoscopic-assisted microscopic procedure to pure EPS. In the initial cases, proper case selection, operative planning, instrumentation with assistance from a surgeon well-versed with the technique would help to make a tangible difference. Also, an attitude in favor of converting EPS to TNTS immediately in case of difficulty would be a good approach to avert any complication.

Endoscopic nasal pituitary surgery with its innovative techniques such as 3D endoscopic system, endoscopic augmented reality navigation system, and ultrasonography-assisted endoscope have increased the safety and revolutionized the concept of pituitary surgeries in developed countries.[1] Despite their relative absence in our part of the world, the results are extremely encouraging.

The EPS is definitely going to replace TNTS, and it is only the time that will decide when, as a famous quote from Steve Jobs says,

“The over-all point is that new technology will not necessarily replace old technology, but it will date it. By definition. Eventually, it will replace it. But it is like people who had black-and-white TVs when color came out. They eventually decided whether or not the new technology was worth the investment.”