Semin Respir Crit Care Med 2019; 40(05): 604-613
DOI: 10.1055/s-0039-1698809
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Pain and Delirium in Critical Illness: An Exploration of Key 2018 SCCM PADIS Guideline Evidence Gaps

Margaret A. Pisani
1   Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
John W. Devlin
3   School of Pharmacy, Northeastern University, Boston, Massachusetts
4   Division of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts
Yoanna Skrobik
2   Department of Medicine, McGill University, Montreal, Quebec, Canada.
› Author Affiliations
Further Information

Publication History

Publication Date:
11 December 2019 (online)


Managing pain and delirium are crucial to patients, families, and caregivers in intensive care units. The Society of Critical Care Medicine 2018 Pain, Agitation/Sedation, Delirium, Immobility, and Sleep disruption (PADIS) guidelines reviewed literature until October 2015 and made its recommendations for critically-ill adults. This chapter addresses evidence gaps, identified during the guideline process, most relevant to clinicians, adds newer evidence published after the PADIS 2018 guidelines were produced, describes hindsight-driven PADIS process or content-related gaps, and reflects on how these considerations may help inform future research investigations and new guideline efforts.

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