CC BY-NC-ND 4.0 · Rev Bras Ortop (Sao Paulo) 2020; 55(01): 017-026
DOI: 10.1055/s-0039-1700813
Artigo de Revisão
Sociedade Brasileira de Ortopedia e Traumatologia. Published by Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Associação do polimorfismo IL-6 -174G > C (rs1800795) com escoliose idiopática da adolescência: Evidências de um estudo de caso-controle e metanálise

Article in several languages: português | English
Mohammad Reza Sobhan
1   Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Masoud Mahdinezhad-Yazdi
1   Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
2   Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
,
Hossein Ahrar
3   Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Kazem Aghili
3   Department of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Hossein Neamatzadeh
4   Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5   Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
› Author Affiliations
Further Information

Publication History

04 September 2018

27 November 2018

Publication Date:
19 December 2019 (online)

Resumo

Estudos epidemiológicos recentes identificaram que o polimorfismo -174G > C (rs1800795) na região promotora do gene interleucina-6 (IL-6) está associado ao risco de desenvolver escoliose idiopática da adolescência (EIA), mas apresentaram resultados inconsistentes e controversos. Assim, realizamos um estudo de caso-controle e metanálise para obter uma estimativa mais precisa da relação entre o polimorfismo IL-6 -174G > C e o risco de desenvolver EIA. Um total de 80 pacientes com EIA e 80 controles saudáveis pareados foram genotipados usando o ensaio de reação em cadeia de polimerase de polimorfismos de comprimento de fragmentos de restrição (RCP-PCFR). Além disso, todos os estudos elegíveis publicados até junho de 2018 foram identificados por meio de uma pesquisa nas bases de dados PubMed, EMBASE, Google Scholar e China National Knowledge Infrastructure (CNKI). Calculamos as razões de probabilidades (RPs) e os intervalos de confiança de 95% (ICs95%) para avaliar a associação. Um total de 10 estudos elegíveis compreendendo 1.695 casos de EIA e 2.097 controles saudáveis foram incluídos na metanálise. Os dados agrupados sugeriram uma associação significativa entre o polimorfismo IL-6 -174G > C e a suscetibilidade a desenvolver EIA que foi demonstrada em quatro modelos genéticos, ou seja, alélico (C versus G; RP = 0,671; IC95%: 0,457–0,985; p = 0,042), heterozigótico (GC versus GG; RP = 0,734; IC95%: 0,554–0,973; p = 0,032), dominante (CC + GC versus GG; RP = 0,660; IC95%: 0,440–0,990; p = 0,044) e recessivo (CC versus CG + GG; RP = 0,506; IC95%: 0,264–0,970; p = 0,040). A análise de estratificação por etnia revelou um aumento do risco de desenvolver EIA em caucasianos, mas não em asiáticos. Esta metanálise, que é inconsistente com relação à metanálise anterior, sugere que o polimorfismo IL-6 -174G > C pode aumentar a suscetibilidade individual para desenvolver EIA, especialmente em caucasianos, e pode servir como um biomarcador para prever a população com alto risco de desenvolver EIA.

 
  • Referências

  • 1 Choudhry MN, Ahmad Z, Verma R. Adolescent Idiopathic Scoliosis. Open Orthop J 2016; 10: 143-154
  • 2 Sobhan MR, Mahdinezhad-Yazdi M, Aghili K. , et al. Association of TNF-α-308G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis. J Orthop 2018; 15 (03) 747-753
  • 3 Beauséjour M, Goulet L, Parent S. , et al. Members of the Quebec Scoliosis Society and of the Canadian Paediatric Spinal Deformities Study Group. The effectiveness of scoliosis screening programs: methods for systematic review and expert panel recommendations formulation. Scoliosis 2013; 8 (01) 12
  • 4 Illés T, Tunyogi-Csapó M, Somoskeöy S. Breakthrough in three-dimensional scoliosis diagnosis: significance of horizontal plane view and vertebra vectors. Eur Spine J 2011; 20 (01) 135-143
  • 5 Wu H, Ronsky JL, Cheriet F, Harder J, Küpper JC, Zernicke RF. Time series spinal radiographs as prognostic factors for scoliosis and progression of spinal deformities. Eur Spine J 2011; 20 (01) 112-117
  • 6 Daryabor A, Arazpour M, Sharifi G, Bani MA, Aboutorabi A, Golchin N. Gait and energy consumption in adolescent idiopathic scoliosis: A literature review. Ann Phys Rehabil Med 2017; 60 (02) 107-116
  • 7 Zheng X, Wang W, Qian B. , et al. Accelerated endochondral growth in adolescents with idiopathic scoliosis: a preliminary histomorphometric study. BMC Musculoskelet Disord 2014; 15 (01) 429
  • 8 Paria N, Wise CA. Genetics of adolescent idiopathic scoliosis. Semin Spine Surg 2015; 27 (01) 9-15
  • 9 Ikegawa S. Genomic study of adolescent idiopathic scoliosis in Japan. Scoliosis Spinal Disord 2016; 11 (01) 5
  • 10 Dai J, Lv ZT, Huang JM, Cheng P, Fang H, Chen AM. Association between polymorphisms in vitamin D receptor gene and adolescent idiopathic scoliosis: a meta-analysis. Eur Spine J 2018; 27 (09) 2175-2183
  • 11 Xu L, Sheng F, Xia C. , et al. Common Variant of POC5 Is Associated With the Susceptibility of Adolescent Idiopathic Scoliosis. Spine 2018; 43 (12) E683-E688
  • 12 Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol 2014; 6 (10) a016295
  • 13 Popko K, Gorska E, Demkow U. Influence of interleukin-6 and G174C polymorphism in IL-6 gene on obesity and energy balance. Eur J Med Res 2010; 15 (Suppl. 02) 123-127
  • 14 Aulisa L, Papaleo P, Pola E. , et al. Association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study. Spine 2007; 32 (24) 2700-2702
  • 15 Zhao J, Yang M, Li M. Association of IL-6 and MMP-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis. J Genet 2016; 95 (03) 573-579
  • 16 Lee JS, Suh KT, Eun IS. Polymorphism in interleukin-6 gene is associated with bone mineral density in patients with adolescent idiopathic scoliosis. J Bone Joint Surg Br 2010; 92 (08) 1118-1122
  • 17 Liu Z, Tang NL, Cao XB. , et al. Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population. Spine 2010; 35 (18) 1701-1705
  • 18 Mórocz M, Czibula A, Grózer ZB. , et al. Association study of BMP4, IL6, Leptin, MMP3, and MTNR1B gene promoter polymorphisms and adolescent idiopathic scoliosis. Spine 2011; 36 (02) E123-E130
  • 19 Nikolova S, Dikova M, Dikov D. , et al. Role of the IL-6 gene in the etiopathogenesis of idiopathic scoliosis. Anal Cell Pathol (Amst) 2015; 2015: 621893
  • 20 Nikolova ST, Yablanski VT, Vlaev EN. , et al. Association Between IL-6 and MMP3 Common Genetic Polymorphisms and Idiopathic Scoliosis in Bulgarian Patients: A Case-control Study. Spine 2016; 41 (09) 785-791
  • 21 Sui W, Yang J, Huang Z, Wang Q, Fan H, Deng Y. Polymorphisms in promoter regions of MMP-3 and IL-6 genes are not associated to adolescent idiopathic scoliosis (AIS) gender bias. J Back Musculoskeletal Rehabil 2017; 30 (03) 559-563
  • 22 Lee JS, Shin JK, Goh TS. Interleukin 6 gene polymorphism in patients with degenerative lumbar scoliosis: a cohort study. Eur Spine J 2018; 27 (03) 607-612
  • 23 Gao J, Zhang L, Liu Z, Yao S, Gao S. [Correlation analysis between interleukin 6 polymorphism and adolescent idiopathic scoliosis susceptibility and bracing effectiveness]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018; 32 (06) 678-684
  • 24 Burwell RG, Dangerfield PH, Moulton A, Grivas TB. Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy. Scoliosis 2011; 6 (01) 26
  • 25 Jafari Nedooshan J, Kargar S, Neamatzadeh H, Haghighi F, Dehghani Mohammad Abadi R, Seddighi N. Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies. Asian Pac J Cancer Prev 2017; 18 (04) 1031-1037
  • 26 Sadeghiyeh T, Hosseini Biouki F, Mazaheri M, Zare-Shehneh M, Neamatzadeh H, Poursharif Z. Association between Catechol-O-Methyltransferase Val158Met (158G/A) Polymorphism and Suicide Susceptibility: A Meta-analysis. J Res Health Sci 2017; 17 (02) e00383
  • 27 Abedinzadeh M, Zare-Shehneh M, Neamatzadeh H, Abedinzadeh M, Karami H. Association between MTHFR C677T polymorphism and risk of prostate cancer: Evidence from 22 studies with 10,832 cases and 11,993 controls. Asian Pac J Cancer Prev 2015; 16 (11) 4525-4530
  • 28 Yazdi MM, Jamalaldini MH, Sobhan MR. , et al. Association of ESRα Gene Pvu II T>C, XbaI A>G and BtgI G>A Polymorphisms with Knee Osteoarthritis Susceptibility: A Systematic Review and Meta-Analysis Based on 22 Case-Control Studies. Arch Bone Jt Surg 2017; 5 (06) 351-362
  • 29 Kamali M, Hamadani S, Neamatzadeh H. , et al. Association of XRCC2 rs3218536 polymorphism with susceptibility of breast and ovarian cancer: A systematic review and meta-analysis. Asian Pac J Cancer Prev 2017; 18 (07) 1743-1749
  • 30 Gohari M, Neámatzadeh H, Jafari MA, Mazaheri M, Zare-Shehneh M, Abbasi-Shavazi E. Association between the p53 codon 72 polymorphism and primary open-angle glaucoma risk: Meta-analysis based on 11 case-control studies. Indian J Ophthalmol 2016; 64 (10) 756-761