J Neurol Surg B Skull Base 2021; 82(03): 378-382
DOI: 10.1055/s-0039-3400223
Original Article

Postoperative Venous Thromboembolism after Neurotologic Surgery

Noor-E-Seher Ali
1   Department of Otolaryngology, Stanford University, Stanford, California, United States
,
Jennifer C. Alyono
1   Department of Otolaryngology, Stanford University, Stanford, California, United States
,
Yohan Song
1   Department of Otolaryngology, Stanford University, Stanford, California, United States
,
Ali Kouhi
1   Department of Otolaryngology, Stanford University, Stanford, California, United States
,
Nikolas H. Blevins
1   Department of Otolaryngology, Stanford University, Stanford, California, United States
› Author Affiliations

Abstract

Objective This study aimed to determine the incidence of postoperative venous thromboembolism (VTE) in adults undergoing neurotologic surgery at a single center.

Methods The records of adults undergoing neurotologic surgery from August 2009 to December 2016 at a tertiary care hospital were reviewed for VTE within 30 postoperative days. Particular attention was focused on postoperative diagnosis codes, imaging, and a keyword search of postoperative notes. Caprini risk scores were calculated.

Results Among 387 patients, 5 experienced postoperative VTE including 3 cases of pulmonary embolism (PE) and 2 cases of isolated deep vein thrombosis (DVT). All patients were given sequential compression devices perioperatively, and none received preoperative chemoprophylaxis. Patients with Caprini score > 8 had a significantly higher rate of VTE compared with those < 8 (12.5 vs. 1%, p = 0.004). Receiver operating characteristic analysis revealed the Caprini risk assessment model to be a fair predictor of VTE, with a C-statistic of 0.70 (95% confidence interval [CI]: 0.49–0.92).

Conclusion While no specific validated VTE risk stratification scheme has been widely accepted for patients undergoing neurotologic surgery, the Caprini score appears to be a useful predictor of risk. The benefits of chemoprophylaxis should be balanced with the risks of intraoperative bleeding, as well as the potential for postoperative intracranial hemorrhage.



Publication History

Received: 17 May 2019

Accepted: 28 September 2019

Article published online:
14 November 2019

© 2019. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Sokoya M, Mourad M, Ducic Y. Complications of skull base surgery. Semin Plast Surg 2017; 31 (04) 227-230
  • 2 Agnelli G, Piovella F, Buoncristiani P. et al. Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med 1998; 339 (02) 80-85
  • 3 Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon 2005; 51 (2,3): 70-78
  • 4 Stroud W, Whitworth JM, Miklic M. et al. Validation of a venous thromboembolism risk assessment model in gynecologic oncology. Gynecol Oncol 2014; 134 (01) 160-163
  • 5 Pannucci CJ, Bailey SH, Dreszer G. et al. Validation of the Caprini risk assessment model in plastic and reconstructive surgery patients. J Am Coll Surg 2011; 212 (01) 105-112
  • 6 Pannucci CJ, Swistun L, MacDonald JK, Henke PK, Brooke BS. Individualized venous thromboembolism risk stratification using the 2005 Caprini score to identify the benefits and harms of chemoprophylaxis in surgical patients: a meta-analysis. Ann Surg 2017; 265 (06) 1094-1103
  • 7 Yarlagadda BB, Brook CD, Stein DJ, Jalisi S. Venous thromboembolism in otolaryngology surgical inpatients receiving chemoprophylaxis. Head Neck 2014; 36 (08) 1087-1093
  • 8 Cramer JD, Dilger AE, Schneider A, Smith SS, Samant S, Patel UA. Risk of venous thromboembolism among otolaryngology patients vs general surgery and plastic surgery patients. JAMA Otolaryngol Head Neck Surg 2018; 144 (01) 9-17
  • 9 Beswick DM, Vaezeafshar R, Ma Y, Hwang PH, Nayak JV, Patel ZM. Risk stratification for postoperative venous thromboembolism after endoscopic sinus surgery. Otolaryngol Head Neck Surg 2018; 158 (04) 767-773
  • 10 Rudy SF, Li K, Moubayed SP, Most SP. Risk of venous thromboembolism in patients with keratinocyte carcinoma. JAMA Facial Plast Surg 2018; 20 (06) 453-459
  • 11 Shuman AG, Hu HM, Pannucci CJ, Jackson CR, Bradford CR, Bahl V. Stratifying the risk of venous thromboembolism in otolaryngology. Otolaryngol Head Neck Surg 2012; 146 (05) 719-724
  • 12 Innis WP, Anderson TD. Deep venous thrombosis and pulmonary embolism in otolaryngologic patients. Am J Otolaryngol 2009; 30 (04) 230-233
  • 13 Chiesa Estomba C, Rivera Schmitz T, Ossa Echeverri CC, Betances Reinoso FA, Osorio Velasquez A, Santidrian Hidalgo C. The risk of venous thromboembolism in ENT and head & neck surgery. Otolaryngol Pol 2015; 69 (03) 31-36
  • 14 Lowe HJ, Ferris TA, Hernandez PM, Weber SC. STRIDE–an integrated standards-based translational research informatics platform. AMIA Annu Symp Proc 2009; 2009: 391-395
  • 15 Casazza GC, Bowers CA, MacDonald JD, Couldwell WT, Shelton C, Gurgel RK. What is the safety and efficacy of chemical venous thromboembolism prophylaxis following vestibular schwannoma surgery?. Otol Neurotol 2018; 39 (02) e131-e136
  • 16 Song Y, Alyono JC, Ali NE, Blevins NH. Postoperative venous thromboembolism after extracranial otologic surgery. Otolaryngol Head Neck Surg 2019; 161 (01) 144-149
  • 17 Gould MK, Garcia DA, Wren SM. et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (2, Suppl): e227S-e277S
  • 18 Geerts WH, Bergqvist D, Pineo GF. et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (6, Suppl): 381S-453S
  • 19 Hollyoak M, Woodruff P, Muller M, Daunt N, Weir P. Deep venous thrombosis in postoperative vascular surgical patients: a frequent finding without prophylaxis. J Vasc Surg 2001; 34 (04) 656-660
  • 20 Faraoni D, Comes RF, Geerts W, Wiles MD. ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: neurosurgery. Eur J Anaesthesiol 2018; 35 (02) 90-95
  • 21 Sweetland S, Green J, Liu B. et al; Million Women Study collaborators. Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ 2009; 339: b4583
  • 22 Dearborn JT, Hu SS, Tribus CB, Bradford DS. Thromboembolic complications after major thoracolumbar spine surgery. Spine 1999; 24 (14) 1471-1476
  • 23 Smith MD, Bressler EL, Lonstein JE, Winter R, Pinto MR, Denis F. Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine. A prospective analysis of three hundred and seventeen patients. J Bone Joint Surg Am 1994; 76 (07) 980-985