Thorac Cardiovasc Surg 2021; 69(01): 043-048
DOI: 10.1055/s-0039-3400538
Original Cardiovascular

Further Evolution of a New Nonbiological Transcatheter Valvular Prosthesis

1  Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany
,
Martin Hartrumpf
1  Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany
,
Ralf-Uwe Kuehnel
1  Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany
,
Roya Ostovar
1  Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany
,
Johannes M. Albes
1  Department of Cardiovascular Surgery, Heart Center Brandenburg, Brandenburg Medical School, Bernau bei Berlin, Brandenburg, Germany
› Author Affiliations
Funding Statement This work was supported by funding of the Brandenburg State Ministry of Science, Research, and Culture. Project Name: INNOVALVE, Germany 2017–2018.

Abstract

Background Polymeric heart valves are constructed from flexible synthetic materials, therefore aiming to combine the advantageous hemodynamic of biological and the longevity of mechanical valve prostheses. One such valve prototype in development is the PIZZA valve constructed of flexible triangular silicone leaflets on a foldable metal base for perspective transcatheter implantation. Here we present further improvements in its performance through structural modifications.

Methods Structurally modified prototypes were constructed from silicone sheets and stainless-steel wires. Their performance was then tested in a hemodynamic testing device of the type HKP 2.0.

Results Shift from a planar to a cone shape as well as overlapping of the leaflets significantly improved the valves performance, reducing regurgitation as well as systolic pressure gradients.

Conclusions The results of the modified prototypes expressed superior performance and represented a step forward on the road to an easily producible, polymeric transcatheter valvular prosthesis.



Publication History

Received: 06 June 2019

Accepted: 13 October 2019

Publication Date:
13 December 2019 (online)

© 2019. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany