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Thorac Cardiovasc Surg 2020; 68(06): 525-532
DOI: 10.1055/s-0039-3400999
Original Thoracic

Preoperative Computed Tomography-Guided Localization for Pulmonary Nodules with Glue and Dye

Tian Jiang‡   *
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Miao Lin‡   *
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Mengnan Zhao
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Cheng Zhan
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Ming Li
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Mingxiang Feng
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
,
Qun Wang
1   Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China
› Author Affiliations Funding This work was supported by the National Natural Science Foundation of China (Grant No. 81672268).
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Abstract

Background This study was aimed to describe a new localization technique developed using medical glue and methylene blue dye, and characterized the localization results and postoperative outcome to evaluate its safety and usefulness.

Methods This retrospective study was conducted at our center from January 2016 to April 2018. Totally 346 consecutive patients with 383 nodules who underwent preoperative computed tomography (CT)-guided medical glue and methylene blue dye localization, followed by lung resection, were enrolled in this study.

Results Mean nodule size was 7.7 ± 3.7 mm (range: 2–30 mm), with a mean depth from pleura or fissure of 9.4 ± 9.3 mm (range: 0–60 mm). The success rate of CT-guided localization for pulmonary nodules was 99.5% (381/383) of the nodules. Localization-related complications included mild pneumothorax in 16 (4.6%) patients, mild hemothorax in 7 (2.0%) patients, and hemoptysis in 1 (0.3%) patient. Pleural reaction occurred in 7 (2.0%) and pain in 25 (7.2%) patients. All 383 nodules were resected successfully, with conversion to thoracotomy only required in two patients for adhesion and calcification of lymph nodes. All patients recovered well postoperatively, with a short postoperative hospital stay (3.7 ± 2.0 days) and a low complication rate (2.6%, 9/346).

Conclusion CT-guided medical glue and methylene blue dye localization prior to video-assisted thoracoscopic surgery (VATS) lung resection was a novel, safe, and technically feasible method, with a high-technical success rate and a low-complication rate. It allowed surgeons to easily locate and detect the nodules and estimate the surgical margin.

Keywords

computed tomography - CT scan - thoracoscopy/VATS - lung cancer

Authors' Contribution

Tian Jiang: study design, analysis and interpretation of data, drafting the article, and final approval.


Miao Lin: study design, analysis and interpretation of data, drafting the article, and final approval.


Mengnan Zhao: interpretation of data, drafting the article, and final approval.


Ming Li: analysis and interpretation of data, drafting the article, and final approval.


Cheng Zhan: acquisition of data, drafting the article, and final approval.


Mingxiang Feng: study design, acquisition of data, drafting the article, revising the article critically for important intellectual content, and final approval.


Qun Wang: study design, drafting the article, revising the article critically for important intellectual content, and final approval.


* Authors Tian Jiang and Miao Lin contributed equally to this work.




Publication History

Received: 07 March 2019

Accepted: 28 October 2019

Article published online:
01 March 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 

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