Thorac Cardiovasc Surg 2021; 69(01): 109-112
DOI: 10.1055/s-0039-3402725
Original Thoracic

Elective Lung Resections in the Elderly: Where Do We Draw the Line?

1   Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom
,
Christopher A. Lovejoy
1   Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom
,
Rudrik Thakker
1   Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom
,
Ian Hunt
1   Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom
,
Fionna Martin
2   Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
,
Carol Tan
1   Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom
› Institutsangaben

Abstract

Introduction The increasing longevity of the Western population means patients with a more advanced age are being diagnosed with resectable disease. With improvements in imaging and diagnostic capabilities, this trend is likely to develop further. As a unit operating on a higher proportion of older patients and with limited literature regarding the population of older than 85 years, we retrospectively compared the outcomes of patients older than 85 years in our unit treated with elective lung resection for non-small cell lung cancer (NSCLC) with those between the age of 80 and 84 years inclusive.

Methods All patients who underwent elective lung cancer resection between the years 2012 and 2015 were identified from the National Thoracic Surgical Database.

Results A total of 701 elective lung resections were performed during this time frame; 76 patients between the ages of 80 and 84 years and 18 patients older than 85 years. The follow-up period was 3 to 7 years. There was a significant increase in the Thoracic Surgery Scoring System (2.04; 2.96%, p = 0.0015) and a significant reduction in the transfer factor (94.7; 69.5%, p = 0.0001) between the younger and older groups. There were three (3.9%) in-hospital deaths in the 80 to 84 years age group and no in-hospital deaths in the 85 years and older age group.

Conclusion This study demonstrates that surgery for early NSCLC can be safely performed in 85 years and older population. This is a higher risk population and parenchymal-sparing procedures should be considered.

Disclosures

There are no sources of funding for the work to declare.




Publikationsverlauf

Eingereicht: 19. August 2019

Angenommen: 28. November 2019

Artikel online veröffentlicht:
28. Januar 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Khuri SF, Daley J, Henderson W. et al. Risk adjustment of the postoperative mortality rate for the comparative assessment of the quality of surgical care: results of the National Veterans Affairs Surgical Risk Study. J Am Coll Surg 1997; 185 (04) 315-327
  • 2 Ahmed HZ, Liu Y, O'Connell K. et al. Guideline-concordant care improves overall survival for locally advanced non-small-cell lung carcinoma patients: a National Cancer Database analysis. Clin Lung Cancer 2017; 18 (06) 706-718
  • 3 Aberle DR, Adams AM, Berg CD. et al; National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365 (05) 395-409
  • 4 Venuta F, Diso D, Onorati I, Anile M, Mantovani S, Rendina EA. Lung cancer in elderly patients. J Thorac Dis 2016; 8 (Suppl. 11) S908-S914
  • 5 Bravo-Iñiguez C, Perez Martinez M, Armstrong KW, Jaklitsch MT. Surgical resection of lung cancer in the elderly. Thorac Surg Clin 2014; 24 (04) 371-381
  • 6 Shepherd SJ, Klein AA, Martinez G. Enhanced recovery for thoracic surgery in the elderly. Curr Opin Anaesthesiol 2018; 31 (01) 30-38
  • 7 Allen MS, Darling GE, Pechet TT. et al; ACOSOG Z0030 Study Group. Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg 2006; 81 (03) 1013-1019 , discussion 1019–1020
  • 8 Wang H-H, Zhang C-Z, Zhang B-L. et al. Sublobar resection is associated with improved outcomes over radiotherapy in the management of high-risk elderly patients with stage I non-small cell lung cancer: a systematic review and meta-analysis. Oncotarget 2017; 8 (04) 6033-6042
  • 9 Kamel MK, Port JL. Oncologic considerations in the elderly. Curr Opin Anaesthesiol 2018; 31 (01) 6-10
  • 10 Polanczyk CA, Marcantonio E, Goldman L. et al. Impact of age on perioperative complications and length of stay in patients undergoing noncardiac surgery. Ann Intern Med 2001; 134 (08) 637-643
  • 11 Partridge JS, Harari D, Dhesi JK. Frailty in the older surgical patient: a review. Age Ageing 2012; 41 (02) 142-147
  • 12 Liu LL, Leung JM. Predicting adverse postoperative outcomes in patients aged 80 years or older. J Am Geriatr Soc 2000; 48 (04) 405-412
  • 13 Falcoz PE, Conti M, Brouchet L. et al. The Thoracic Surgery Scoring System (Thoracoscore): risk model for in-hospital death in 15,183 patients requiring thoracic surgery. J Thorac Cardiovasc Surg 2007; 133 (02) 325-332
  • 14 Lim E, Baldwin D, Beckles M. et al; British Thoracic Society; Society for Cardiothoracic Surgery in Great Britain and Ireland. Guidelines on the radical management of patients with lung cancer. Thorax 2010; 65 (Suppl. 03) iii1-iii27
  • 15 Lung Cancer Surgery Consultant Outcomes Publication (LCCOP) data. Accessed February 2, 2019 at: https://scts.org/outcomes/thoracic/
  • 16 Partridge JS, Harari D, Martin FC. et al. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery. Br J Surg 2017; 104 (06) 679-687
  • 17 Getting it Right First Time (GIRFT) report 2018. Accessed February 2, 2019. Available at: http://gettingitrightfirsttime.co.uk/wp-content/uploads/2018/04/GIRFT-Cardiothoracic-Report-1.pdf
  • 18 Lin H-S, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr 2016; 16 (01) 157
  • 19 Kim DH, Kim CA, Placide S, Lipsitz LA, Marcantonio ER. Preoperative frailty assessment and outcomes at 6 months or later in older adults undergoing cardiac surgical procedures: a systematic review. Ann Intern Med 2016; 165 (09) 650-660
  • 20 Beggs T, Sepehri A, Szwajcer A, Tangri N, Arora RC. Frailty and perioperative outcomes: a narrative review. Can J Anaesth 2015; 62 (02) 143-157
  • 21 Gagné S, McIsaac DI. Modifiable risk factors for patients undergoing lung cancer surgery and their optimization: a review. J Thorac Dis 2018; 10 (Suppl. 32) S3761-S3772
  • 22 Bagnall NM, Faiz O, Darzi A, Athanasiou T. What is the utility of preoperative frailty assessment for risk stratification in cardiac surgery?. Interact Cardiovasc Thorac Surg 2013; 17 (02) 398-402
  • 23 Dunne MJ, Abah U, Scarci M. Frailty assessment in thoracic surgery. Interact Cardiovasc Thorac Surg 2014; 18 (05) 667-670
  • 24 Partridge JS, Dhesi JK, Cross JD. et al. The prevalence and impact of undiagnosed cognitive impairment in older vascular surgical patients. J Vasc Surg 2014; 60 (04) 1002-11.e3
  • 25 Partridge JS, Fuller M, Harari D, Taylor PR, Martin FC, Dhesi JK. Frailty and poor functional status are common in arterial vascular surgical patients and affect postoperative outcomes. Int J Surg 2015; 18: 57-63
  • 26 Ginsberg RJ, Rubinstein LV. Lung Cancer Study Group. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Ann Thorac Surg 1995; 60 (03) 615-622 , discussion 622–623
  • 27 Razi SS, John MM, Sainathan S, Stavropoulos C. Sublobar resection is equivalent to lobectomy for T1a non-small cell lung cancer in the elderly: a Surveillance, Epidemiology, and End Results database analysis. J Surg Res 2016; 200 (02) 683-689
  • 28 Mery CM, Pappas AN, Bueno R. et al. Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the Surveillance, Epidemiology, and End Results database. Chest 2005; 128 (01) 237-245
  • 29 Rueth NM, Parsons HM, Habermann EB. et al. Surgical treatment of lung cancer: predicting postoperative morbidity in the elderly population. J Thorac Cardiovasc Surg 2012; 143 (06) 1314-1323
  • 30 Cattaneo SM, Park BJ, Wilton AS. et al. Use of video-assisted thoracic surgery for lobectomy in the elderly results in fewer complications. Ann Thorac Surg 2008; 85 (01) 231-235 , discussion 235–236