Hamostaseologie 2020; 40(01): 084-087
DOI: 10.1055/s-0040-1701475
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Diagnostic Challenges in Newborns and Infants with Coagulation Disorders

Wolfgang Eberl
1   Department of Pediatrics, Städtisches Klinikum Braunschweig, Braunschweig, Germany
› Author Affiliations
Further Information

Publication History

19 August 2019

27 November 2019

Publication Date:
12 February 2020 (online)

Abstract

Laboratory diagnostics in children and adolescents, especially in newborns and very small children, differ considerably compared with laboratory diagnostics in adults. This applies to all individual steps of the examination (i.e., the indication, the preanalytical phase, the analysis itself, and interpretation of the findings). This is particularly true in the diagnostics of hemostasis, in which small sample volumes and relatively error prone coagulation tests are posing particular challenges to the strategy, performance, and evaluation of the tests. Differences in the individual steps are illustrated below.

Zusammenfassung

Labordiagnostik im Kindes - und Jugendalter, vor allem bei Neugeborenen und Säuglingen unterscheidet sich erheblich von Untersuchungen bei Erwachsenen. Dies betrifft alle Schritte der Untersuchung (Indikation, präanalytische Phase, Analyse und Befundinterpretation). Bei der Gerinnungsdiagnostik ist dies besonders deutlich, da die geringe zur Verfügung stehende Probenmenge und die Störempfindlichkeit der Testsysteme hier besondere Herausforderungen an die Planung, Durchführung und Bewertung der Tests stellen. Die Besonderheiten und Unterschiede sollen hier dargestellt werden.

 
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