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J Neurol Surg B Skull Base 2021; 82(S 03): e335-e341
DOI: 10.1055/s-0040-1701677
Original Article

Computed Tomography as a Predictor of Sinonasal Inverted Papilloma Origin, Skull Base Involvement, and Stage

Jake J. Lee
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
,
Hilary L. P. Orlowski
2   Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States
,
John S. Schneider
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
,
Lauren T. Roland
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
3   Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, United States
5   Department of Otolaryngology-Head and Neck Surgery, San Francisco School of Medicine, University of California, San Francisco, California, United States
,
Rami Eldaya
2   Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States
,
Pawina Jiramongkolchai
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
,
Dorina Kallogjeri
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
,
Rebecca D. Chernock
4   Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, United States
,
Cristine N. Klatt-Cromwell
1   Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States
› Author Affiliations Funding Research reported in this publication was supported by the National Institutes of Health (NIH) under Award Number 5T32DC000022-30 and by the National Center for Advancing Translational Sciences of the NIH under award number UL1TR002345. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Abstract

Objective To investigate the diagnostic performance of computed tomography (CT) to determine the origin, skull base involvement, and stage of sinonasal inverted papilloma (IP).

Design This is a retrospective cohort study.

Setting This is set at a tertiary care medical center.

Participants Patients with preoperative CT imaging who underwent extirpative surgery for histologically confirmed sinonasal IP between January 2005 and October 2019.

Main Outcome Measures The likely sites of tumor origin, skull base involvement, and radiographic tumor stage were determined by two board-certified neuroradiologists after re-reviewing preoperative CT imaging. These radiologic findings were then compared with intraoperative and pathologic findings.

Results Of 86 patients, 74% (64/86) had IP lesions with correctly classified sites of origin on CT. CT was not sensitive for diagnosing ethmoid sinus origin (48%, 52%), frontal sinus origin (80%, 40%), and skull base origin (17%, 17%). CT was not sensitive (62%, 57%) but specific (86%, 98%) for identifying any skull base involvement. There was substantial-to-near perfect agreement between radiographic and pathologic Cannady stages (weighted κ = 0.61 for rater 1; weighted κ = 0.81 for rater 2). Interrater agreement was substantial for identifying tumor origin (κ = 0.75) and stage (weighted κ = 0.62) and moderate for identifying skull base involvement (κ = 0.43).

Conclusion Interrater agreement on CT findings was substantial except on skull base involvement. CT correctly predicted site of tumor origin in up to 74% of subjects. CT was not sensitive for diagnosing skull base involvement but had substantial-to-near perfect agreement with pathologic tumor staging. CT is a useful but albeit limited adjunct for tumor localization and surgical planning for sinonasal IP.

Keywords

inverted papilloma - paranasal sinus - origin - skull base - stage - computed tomography

Note

Poster presented at the North American Skull Base Society 2019 Annual Meeting, Orlando, Florida, United States, February 16, 2019.




Publication History

Received: 10 May 2019

Accepted: 31 December 2019

Article published online:
20 February 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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