J Neurol Surg B Skull Base 2020; 81(S 01): S1-S272
DOI: 10.1055/s-0040-1702671
Poster Presentations
Georg Thieme Verlag KG Stuttgart · New York

Perineural Spread of the Facial Nerve from Cutaneous Squamous Cell Carcinoma of the Head and Neck: Epidemiology and Survival Outcomes

Michael Schachtel
1   Princess Alexandra Hospital, Brisbane, Australia
,
Ben Panizza
1   Princess Alexandra Hospital, Brisbane, Australia
,
James Bowman
1   Princess Alexandra Hospital, Brisbane, Australia
,
Mitesh Gandhi
1   Princess Alexandra Hospital, Brisbane, Australia
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Publikationsverlauf

Publikationsdatum:
05. Februar 2020 (online)

 

Introduction: Perineural spread (PNS) from cutaneous head and neck malignancies has traditionally been a rare disease that is poorly understood. This has led to diagnostic delays, resulting in poorer outcomes and more debilitating treatments. In areas such as Queensland (Australia), where nonmelanoma skin cancer (NMSC) rates are extraordinarily high, PNS is becoming more prevalent, likely in part due to an increased awareness of the disease. While understanding of the disease process is becoming clearer, PNS still poses unique therapeutic challenges and can be associated with poor outcomes. Multiple previous studies have investigated outcomes of patients with PNS from cutaneous squamous cell carcinoma (SCC) of the head and neck, however few have exclusively studied PNS of the facial (VII) nerve.

Objective: To evaluate the epidemiology, patterns of spread, survival outcomes, and prognostic factors of patients with PNS of the VII nerve from cutaneous squamous cell carcinoma of the head and neck.

Methods: This is a retrospective cohort study of 60 consecutive patients* with PNS of the VII nerve from cutaneous squamous cell carcinoma of the head and neck managed at a tertiary care center between 2000 and 2019. Data were collected on demographics, primary tumor, disease extent, treatment, histopathology, and survival outcome. All patients were staged according to the Williams Zonal Classification for PNS and the AJCC 8th edition TNM Staging System. Kaplan-Meier survival analysis was performed, and prognostic factors were identified through uni- and multivariate analysis.

Results: This is the largest ever case series on PNS of the VII nerve from cutaneous squamous cell carcinoma of the head and neck. Data collection is being finalized and analysis be completed before the end of 2019.

Conclusion: Conclusions will be drawn once data analysis is complete.

*Final patient numbers TBD but will be at least 60.