Download PDF
CC BY 4.0 · Glob Med Genet 2020; 07(01): 008-013
DOI: 10.1055/s-0040-1710548
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Meta-Analysis on the Association of C-Reactive Protein Polymorphisms with Metabolic Syndrome

Seyedeh Maryam Sharafi
1   Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
,
Manijeh Mahdavi
2   Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
,
Roya Riahi
3   Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
,
Majid Kheirollahi
2   Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
4   Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
,
Roya Kelishadi
3   Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2020 (online)

   Permissions and Reprints

Abstract

Polymorphisms in the C-reactive protein (CRP) genes might have crucial role in the development of metabolic syndrome (MetS). In the current comprehensive meta-analyses, we aim to provide a quantitative assessment of the association between CRP single-nucleotide polymorphisms (SNPs) and the risk of MetS. An electronic search was performed on several databases. After data extraction, random effect model was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Four independent studies including case–control, cohort, and cross-sectional methods were analyzed. Our meta-analysis indicated that CRP polymorphisms are not significantly associated with MetS (OR = 0.92, 95% CI = 0.77–1.10) with significant heterogeneity (I 2 = 55.4%; p-value = 0.008). The subgroup analysis revealed that only GG has significant association with MetS (OR = 0.32, 95% CI = 0.13–0.80, p-value = 0.015) without significant heterogeneity (I 2 = 0%, p-value > 0.05). In conclusion, this meta-analysis provides strong evidence that only some SNPs of CRP gene are associated with the risk for development of MetS; and this relationship does not exist in different ethnic populations.

Keywords

C-reactive protein - single-nucleotide polymorphisms (SNPs) - metabolic syndrome - meta-analysis
 

  • References

  • 1 Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med 2006; 23 (05) 469-480
    CrossrefPubMedGoogle Scholar
  • 2 Timpson NJ, Lawlor DA, Harbord RM. , et al. C-reactive protein and its role in metabolic syndrome: Mendelian randomisation study. Lancet 2005; 366 (9501): 1954-1959
    CrossrefPubMedGoogle Scholar
  • 3 Ueyama C, Horibe H, Yamase Y. , et al. Association of FURIN and ZPR1 polymorphisms with metabolic syndrome. Biomed Rep 2015; 3 (05) 641-647
    CrossrefPubMedGoogle Scholar
  • 4 Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 2003; 107 (03) 391-397
    CrossrefPubMedGoogle Scholar
  • 5 Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 2003; 107 (03) 363-369
    CrossrefPubMedGoogle Scholar
  • 6 Kuo HK, Yen CJ, Chang CH, Kuo CK, Chen JH, Sorond F. Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol 2005; 4 (06) 371-380
    CrossrefPubMedGoogle Scholar
  • 7 Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340 (06) 448-454
    CrossrefPubMedGoogle Scholar
  • 8 Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop I, López-Narváez ML, Álvarez-Cámara JF, González-Castro TB. Association between CRP and TNF-α genes variants and cardiovascular heart disease in a Mexican population: protocol for a case-control study. Int J Environ Res Public Health 2016; 13 (01) 103
    CrossrefPubMedGoogle Scholar
  • 9 Komurcu-Bayrak E, Erginel-Unaltuna N, Onat A. , et al. Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults. Atherosclerosis 2009; 206 (02) 474-479
    CrossrefPubMedGoogle Scholar
  • 10 Abd El-Aziz TA, Mohamed RH. Human C-reactive protein gene polymorphism and metabolic syndrome are associated with premature coronary artery disease. Gene 2013; 532 (02) 216-221
    CrossrefPubMedGoogle Scholar
  • 11 Gaysina D, Pierce M, Richards M, Hotopf M, Hardy R. Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms. Int J Neuropsychopharmacol 2010; 13: 168-169
    Google Scholar
  • 12 Hsu LA, Chang CJ, Wu S. , et al. Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects. Metabolism 2010; 59 (12) 1710-1716
    CrossrefPubMedGoogle Scholar
  • 13 Nikpour P, Emadi-Baygi M, Fatemi SG, Kelishadi R. Absence of association between -286C>A>T polymorphism in the CRP gene and metabolic syndrome in Iranian pediatric. Adv Biomed Res 2015; 4: 210
    PubMedGoogle Scholar
  • 14 Wessel J, Moratorio G, Rao F. , et al. C-reactive protein, an ‘intermediate phenotype’ for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens 2007; 25 (02) 329-343
    CrossrefPubMedGoogle Scholar
  • 15 Chen AR, Zhang HG, Wang ZP. , et al. C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population. Clin Invest Med 2010; 33 (05) E290-E297
    PubMedGoogle Scholar
  • 16 Hage FG, Szalai AJ. The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk. Curr Atheroscler Rep 2009; 11 (02) 124-130
    CrossrefPubMedGoogle Scholar