CC BY-NC-ND 4.0 · Laryngorhinootologie 2020; 99(S 02): S398
DOI: 10.1055/s-0040-1711442
Salivary Glands / Thyroid Glands

Importance of Acoustic Radiation Force Impulse (ARFI) in the diagnosis of primary Sjögren’s syndrome according to American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR)

M Wagner
1  Universitätsklinikum Freiburg, HNO, Freiburg
N Mansour
1  Universitätsklinikum Freiburg, HNO, Freiburg
Thea C. Reuter
1  Universitätsklinikum Freiburg, HNO, Freiburg
B Hofauer
1  Universitätsklinikum Freiburg, HNO, Freiburg
A Knopf
1  Universitätsklinikum Freiburg, HNO, Freiburg
› Institutsangaben

Introduction The aim of the study is to evaluate ARFI technology in the diagnosis of primary Sjögren’s syndrome (pSS), in view of revised diagnostic criteria by ACR/EULAR and limited sensitivity of the American-European Consensus Group (AECD) diagnostic criteria for the ENT cohort.

Methods In this retrospective study, 157 patients with Sicca symptoms and/or salivary gland swelling were included. The evaluation was carried out on Schirmer test, Unstimulated Whole Saliva (UWS), SS-A antibodies and histology according to ACR/EULAR criteria. Ultrasound and ARFI examinations of Glandula parotis and submandibularis were available for all patients.

Results A total of 57 patients with ACR/EULAR pSS were identified, compared to 70 patients by AECD. Sensitivity and specificity were shown to be almost unchanged for Schirmer test and ARFI technology, increased for SS-A. For UWS, the specificity increased with constant sensitivity. For histology, there was an increase in sensitivity when specificity collapsed.

A good correlation according to Pearson was found between ARFI technology and old and new diagnostic criteria, a low correlation with xerostomy and xerophthalmia and no correlation with histology.

Conclusions The revised diagnostic criteria according to ACR/EULAR focus on objective findings. The sensitive but little specific diagnostic criteria of xerostomy and xerophthalmia have been removed. A determination of the Ocular Staining Score should be made for diagnosis according to recommendation, otherwise diagnosis will be difficult. ARFI as a sensitive and robust method has the potential to enable an earlier diagnosis of pSS, especially for the ENT cohort.

Poster-PDF A-1458.PDF


10. Juni 2020 (online)

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