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J Knee Surg 2022; 35(02): 159-166
DOI: 10.1055/s-0040-1713658
Original Article

Baseline Analysis of Patients Presenting for Surgical Review of Anterior Cruciate Ligament Rupture Reveals Heterogeneity in Patient-Reported Outcome Measures

Authors

  • Chee Han Ting

    1   Department of Orthopaedics, QEII Jubilee Hospital, Coopers Plains, Queensland, Australia

  • Corey Scholes 

    2   EBM Analytics, Sydney, New South Wales, Australia

  • David Zbrojkiewicz

    1   Department of Orthopaedics, QEII Jubilee Hospital, Coopers Plains, Queensland, Australia

  • Christopher Bell

    1   Department of Orthopaedics, QEII Jubilee Hospital, Coopers Plains, Queensland, Australia

Funding This study was funded by the Queen Elizabeth II Jubilee Hospital Orthopaedic Research Fund.
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Abstract

Despite the establishment of successful surgical techniques and rehabilitation protocols for anterior cruciate ligament (ACL) reconstruction, published return to sport rates are less than satisfactory. This has led orthopaedic surgeons and researchers to develop more robust patient selection methods, and investigate prognostic patient characteristics. No previous studies have integrated baseline characteristics and responses to patient-reported outcome measures (PROMs) of patients with ACL rupture presenting for surgical review. Patients electing to undergo ACL reconstruction under the care of a single orthopaedic surgeon at a metropolitan public hospital were enrolled in a clinical quality registry. Patients completed Veterans RAND 12-item Health Survey (VR-12) Physical Component Summary and Mental Component Summary scores, Tegner activity scale, and International Knee Documentation Committee (IKDC) questionnaires at presentation. Total scores were extracted from the electronic registry, and a machine learning approach (k-means) was used to identify subgroups based on similarity of questionnaire responses. The average scores in each cluster were compared using analysis of variance (ANOVA; Kruskal–Wallis) and nominal logistic regression was performed to determine relationships between cluster membership and patient age, gender, body mass index (BMI), and injury-to-examination delay. A sample of 107 patients with primary ACL rupture were extracted, with 97 (91%) available for analysis with complete datasets. Four clusters were identified with distinct patterns of PROMs responses. These ranged from lowest (Cluster 1) to highest scores for VR-12 and IKDC (Cluster 4). In particular, Cluster 4 returned median scores within 6 points of the patient acceptable symptom state for the IKDC score for ACL reconstruction (70.1, interquartile range: 59–78). Significant (p < 0.05) differences in PROMs between clusters were observed using ANOVA, with variance explained ranging from 40 to 69%. However, cluster membership was not significantly associated with patient age, gender, BMI, or injury-to-examination delay. Patients electing to undergo ACL reconstruction do not conform to a homogenous group but represent a spectrum of knee function, general physical and mental health, and preinjury activity levels, which may not lend itself to uniform treatment and rehabilitation protocols. The factors driving these distinct responses to PROMs remain unknown but are unrelated to common demographic variables.

Keywords

ACL reconstruction - cluster analysis - PROMs - baseline - subgroup

Supplementary Material



Publikationsverlauf

Eingereicht: 06. Februar 2020

Angenommen: 24. Mai 2020

Artikel online veröffentlicht:
06. Juli 2020

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