CC BY 4.0 · Global Medical Genetics 2020; 07(02): 035-040
DOI: 10.1055/s-0040-1714415
Review Article

Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer

Wedad Saeed Al-Qahtani
1  Department of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia
,
Ebtesam Al-Olayan
2  Department of Zoology, College of Science, King Saud University Riyadh, Riyadh, Saudi Arabia
,
Fatimah Gh. Albani
3  Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Rania Saad Suliman
3  Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Nada Hamad Aljarba
3  Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
E.M. Al-Humaidhi
3  Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Alanood S. Almurshedi
4  Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
Dalia Mostafa Domiaty
5  Department of Biology, College of Science, Jeddah University, Jeddah, Saudi Arabia
,
Manal Abdullah Alduwish
6  Department of Biology, Prince Sattam bin Abdulaziz University, College of Science and Humanities, Alkarj, Saudi Arabia
,
Aljohara M. Al-Otaibi
3  Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Abdelbaset Mohamed Elasbali
7  Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi Arabia
,
Hussain Gadelkarim Ahmed
8  College of Medicine, University of Hail, Hail, Saudi Arabia
9  Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Hail, Saudi Arabia
10  Department of Histopathology and Cytology, CMLS, University of Khartoum, Sudan
,
Bassam Ahmed Almutlaq
8  College of Medicine, University of Hail, Hail, Saudi Arabia
› Author Affiliations
Funding This study was funded by the researchers Supporting Project number (RSP-2019/111), King Saud University, Riyadh, Saudi Arabia.

Abstract

Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM).

Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved.

Results The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions (p < 0.001).

Conclusion The association between T2DM and colon cancer was well-established in the present study.

Ethical Approval

The study was approved by the Ethical Committee at the College of Medicine, University of Hail under the protocol, “EC-00053.”




Publication History

Publication Date:
31 August 2020 (online)

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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