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CC BY 4.0 · Glob Med Genet 2020; 07(02): 035-040
DOI: 10.1055/s-0040-1714415
Review Article

Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer

Wedad Saeed Al-Qahtani
1   Department of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia
,
Ebtesam Al-Olayan
2   Department of Zoology, College of Science, King Saud University Riyadh, Riyadh, Saudi Arabia
,
Fatimah Gh. Albani
3   Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Rania Saad Suliman
3   Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Nada Hamad Aljarba
3   Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
E.M. Al-Humaidhi
3   Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Alanood S. Almurshedi
4   Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
,
Dalia Mostafa Domiaty
5   Department of Biology, College of Science, Jeddah University, Jeddah, Saudi Arabia
,
Manal Abdullah Alduwish
6   Department of Biology, Prince Sattam bin Abdulaziz University, College of Science and Humanities, Alkarj, Saudi Arabia
,
Aljohara M. Al-Otaibi
3   Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
,
Abdelbaset Mohamed Elasbali
7   Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Qurayyat, Saudi Arabia
,
Hussain Gadelkarim Ahmed
8   College of Medicine, University of Hail, Hail, Saudi Arabia
9   Molecular Diagnostics and Personalized Therapeutics Unit, University of Ha'il, Hail, Saudi Arabia
10   Department of Histopathology and Cytology, CMLS, University of Khartoum, Sudan
,
Bassam Ahmed Almutlaq
8   College of Medicine, University of Hail, Hail, Saudi Arabia
› Institutsangaben Funding This study was funded by the researchers Supporting Project number (RSP-2019/111), King Saud University, Riyadh, Saudi Arabia.
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Abstract

Background Cancer and diabetes have a tremendous impact on health globally. This study aimed to evaluate the KRAS gene in colon cancer tissues obtained from patients with type 2 diabetes mellitus (T2DM).

Materials and Methods Data from 315 cases (156 colon diabetics and 159 patients were nondiabetics) were retrospectively retrieved. mRNA from surgically resected colon cancer tumors were also retrieved.

Results The expression of KRAS mRNA was significantly higher in patients afflicted with T2DM than nondiabetic patients. The KRAS mRNA levels were significantly amplified from primary to metastatic lesions (p < 0.001).

Conclusion The association between T2DM and colon cancer was well-established in the present study.

Keywords

colon cancer - KRAS - gene expression - immunohistochemistry - type 2 diabetes

Ethical Approval

The study was approved by the Ethical Committee at the College of Medicine, University of Hail under the protocol, “EC-00053.”




Publikationsverlauf

Artikel online veröffentlicht:
31. August 2020

© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

Georg Thieme Verlag KG
Stuttgart · New York

 

  • References

  • 1 Suh S, Kim KW. Diabetes and cancer: is diabetes causally related to cancer?. Diabetes Metab J 2011; 35 (03) 193-198
    CrossrefPubMedGoogle Scholar
  • 2 Law PJ, Timofeeva M, Fernandez-Rozadilla C. , et al; PRACTICAL consortium. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nat Commun 2019; 10 (01) 2154
    CrossrefPubMedGoogle Scholar
  • 3 Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA. Obesity, diabetes and the risk of colorectal adenoma and cancer. BMC Endocr Disord 2019; 19 (01) 113
    CrossrefPubMedGoogle Scholar
  • 4 Chireh B, D'Arcy C. Shared and unique risk factors for depression and diabetes mellitus in a longitudinal study, implications for prevention: an analysis of a longitudinal population sample aged ⩾ 45 years. Ther Adv Endocrinol Metab 2019; (e-pub ahead of print). DOI: 10.1177/2042018819865828.
    CrossrefPubMedGoogle Scholar
  • 5 Luo J, Lin HC, He K, Hendryx M. Diabetes and prognosis in older persons with colorectal cancer. Br J Cancer 2014; 110 (07) 1847-1854
    CrossrefPubMedGoogle Scholar
  • 6 Huang YC, Lin JK, Chen WS. , et al. Diabetes mellitus negatively impacts survival of patients with colon cancer, particularly in stage II disease. J Cancer Res Clin Oncol 2011; 137 (02) 211-220
    CrossrefPubMedGoogle Scholar
  • 7 Berster JM, Göke B. Type 2 diabetes mellitus as risk factor for colorectal cancer. Arch Physiol Biochem 2008; 114 (01) 84-98
    CrossrefPubMedGoogle Scholar
  • 8 Arrington AK, Heinrich EL, Lee W. , et al. Prognostic and predictive roles of KRAS mutation in colorectal cancer. Int J Mol Sci 2012; 13 (10) 12153-12168
    CrossrefPubMedGoogle Scholar
  • 9 Stephens RM, Yi M, Kessing B, Nissley DV, McCormick F. Tumor RAS gene expression levels are influenced by the mutational status of RAS genes and both upstream and downstream RAS pathway genes. Cancer Inform 2017; (e-pub ahead of print). DOI: 10.1177/1176935117711944.
    CrossrefPubMedGoogle Scholar
  • 10 Yang IS, Kim S. Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients. BMC Bioinformatics 2018; 19 (Suppl. 01) 40
    CrossrefPubMedGoogle Scholar
  • 11 Cicenas J, Tamosaitis L, Kvederaviciute K. , et al. KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma. Med Oncol 2017; 34 (02) 26
    CrossrefPubMedGoogle Scholar
  • 12 Misale S, Yaeger R, Hobor S. , et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 2012; 486 (7404): 532-536
    CrossrefPubMedGoogle Scholar
  • 13 Aldiab A, Al Khayal KA, Al Obaid OA. , et al. Clinicopathological features and predictive factors for colorectal cancer outcome in the Kingdom of Saudi Arabia. Oncology 2017; 92 (02) 75-86
    CrossrefPubMedGoogle Scholar
  • 14 Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. J Cell Sci 2016; 129 (07) 1287-1292
    CrossrefPubMedGoogle Scholar
  • 15 Jarvandi S, Davidson NO, Schootman M. Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality. PLoS One 2013; 8 (09) e74616
    CrossrefPubMedGoogle Scholar
  • 16 Miłek T, Forysiński K, Myrcha P, Ciostek P. Diabetes association of polyps and colon cancer. Pol Przegl Chir 2019; 91 (04) 9-12
    PubMedGoogle Scholar
  • 17 Laish I, Mizrahi J, Naftali T, Konikoff FM. Diabetes mellitus and age are risk factors of interval colon cancer: a case-control study. Dig Dis 2019; 37 (04) 291-296
    CrossrefPubMedGoogle Scholar
  • 18 Noh GY, Hwang DY, Choi YH, Lee YY. Effect of diabetes mellitus on outcomes of colorectal cancer. J Korean Soc Coloproctol 2010; 26 (06) 424-428
    CrossrefPubMedGoogle Scholar
  • 19 Slattery ML, Pellatt DF, Mullany LE, Wolff RK, Herrick JS. Gene expression in colon cancer: A focus on tumor site and molecular phenotype. Genes Chromosomes Cancer 2015; 54 (09) 527-541
    CrossrefPubMedGoogle Scholar
  • 20 Kheirelseid EA, Miller N, Chang KH, Nugent M, Kerin MJ. Clinical applications of gene expression in colorectal cancer. J Gastrointest Oncol 2013; 4 (02) 144-157
    PubMedGoogle Scholar
  • 21 Liang H, Zhang J, Shao C. , et al. Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues. J Exp Clin Cancer Res 2012; 31 (01) 36
    CrossrefPubMedGoogle Scholar
  • 22 Yuhara H, Steinmaus C, Cohen SE, Corley DA, Tei Y, Buffler PA. Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer?. Am J Gastroenterol 2011; 106 (11) 1911-1921 , quiz 1922
    CrossrefPubMedGoogle Scholar
  • 23 Imamura Y, Lochhead P, Yamauchi M. , et al. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Mol Cancer 2014; 13: 135
    CrossrefPubMedGoogle Scholar
  • 24 Dahabreh IJ, Terasawa T, Castaldi PJ, Trikalinos TA. Systematic review: Anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer. Ann Intern Med 2011; 154 (01) 37-49
    CrossrefPubMedGoogle Scholar
  • 25 Johnson DS, Cinnioglu C, Ross R. , et al. Comprehensive analysis of karyotypic mosaicism between trophectoderm and inner cell mass. Molecular human reproduction 2010; 16 (12) 944-949
    CrossrefPubMedGoogle Scholar