Adipositas - Ursachen, Folgeerkrankungen, Therapie 2020; 14(03): 166
DOI: 10.1055/s-0040-1714481
P
Poster

Ciliary dysfunction impairs metabolic activation of brown and white adipose tissue

S Gohlke
1   German Institute of Human Nutrition, Adipocyte Development Research Group,, Nuthetal, Deutschland
2   German Center for Diabetes Research (DZD),, München, Deutschland
,
C Mancini
1   German Institute of Human Nutrition, Adipocyte Development Research Group,, Nuthetal, Deutschland
,
J Gerdes
3   Helmholtz Centre München, Institute for Diabetes and Regeneration Research,, München, Deutschland
,
T Schulz
1   German Institute of Human Nutrition, Adipocyte Development Research Group,, Nuthetal, Deutschland
2   German Center for Diabetes Research (DZD),, München, Deutschland
› Author Affiliations
 

Einleitung Adipose tissue is central to the regulation of energy balance. While white adipose tissue is responsible for triglyceride storage, brown adipose tissue specializes in energy expenditure. Deterioration of brown adipocyte function contributes to the development of metabolic complications like obesity and diabetes. These disorders are also leading symptoms of the Bardet–Biedl syndrome (BBS), a hereditary disorder in humans which is caused by dysfunctions of Bbs gene products that form the BBSome supercomplex at the base of the primary cilium. Cilia are hair-like organelles involved in cellular signal transduction.

Methoden Effects of metabolic activation were analyzed in brown and subcutaneous white adipose tissue of Bbs4 knockout mice to evaluate the role of cilia during adipose tissue remodeling.

Ergebnisse Ciliary dysfunction impairs the metabolic response of adipose tissue to adrenergic stimulation, leading to significant loss of adipose tissue mass when Bbs4 knockout mice are housed in a cold environment. This is accompanied by cold-intolerance and alterations of fatty acid metabolism. Furthermore, pharmacologic β-adrenergic stimulation uncovers impaired browning capacity of subcutaneous white adipose tissue.

Schlussfolgerung These findings taken together suggest that cilia-dependent signal transduction is essential for the regulation of adipose tissue metabolism, representing a potential target to treat metabolic disorders.



Publication History

Article published online:
04 September 2020

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