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J Neurol Surg B Skull Base 2021; 82(06): 700-708
DOI: 10.1055/s-0040-1715593
Original Article

The Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Development

Nuray Bayar Muluk 
1   Department of Ear, Nose, and Throat, Kirikkale University, Faculty of Medicine, Kirikkale, Turkey
,
Osman Kürşat Arikan
2   Department of Ear, Nose and Throat, Private Adana Ortadoğu Hospital, Adana, Turkey
,
Pınar Atasoy
3   Department of Pathology, Koç University Hospital, Istanbul, Turkey
,
Rahmi Kiliç
4   Ear, Nose, and Throat Clinics, Ankara Training and Research Hospital, Ankara, Turkey
,
Eda Tuna Yalçinozan
5   Department of Otorhinolaryngology-Head and Neck Surgery, Near East University School of Medicine, Nicosia, Cyprus
› Author Affiliations Funding This study was supported by “Kirikkale University Scientific Research Projects Coordination Unit Funds” (date: 2009, number: 2009/16).
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Abstract

Objectives The aim of this study was to investigate the role of CD68 (+) histiocytic macrophages (H-M) in the nasal polyp pathogenesis.

Materials and Methods The study group consisted of 24 adult patients with nasal polyposis. The control group consisted of 11 adult patients without nasal polyps. A total of 36 nasal polyp samples (10-nasal cavity, 10-maxillary sinus, and 16-ethmoid sinus) from the study group and 11 inferior turbinate samples from the control group were analyzed by immunohistochemical staining, with monoclonal antibodies against CD68 (+) H-M.

Results CD68 positivity was significantly higher than the control group in the subepithelial (SE) layer of the ethmoid sinus, and deep layers of nasal cavity, maxillary, and ethmoid sinuses. In SE and deep layers of ethmoid and maxillary sinuses, CD68 positivity was significantly higher than that of the epithelial layer. In the deep layer, histiocytic macrophages tended to gather around eosinophils.

Conclusion The high numbers of CD68 (+) histiocytic macrophages mainly located in deep layer of lamina propria may be responsible for the phagocytosis of eosinophils within the polyp tissue. Therefore, it may be concluded that increased macrophages in nasal polyps do not trigger the growth of nasal polyps. Instead, they may serve to reduce the number of eosinophils in already-developed nasal polyps.

Keywords

CD68 (+) - histiocytic macrophages - polyp - ethmoid sinus - maxillary sinus - nasal cavity - pathogenesis

Authors' Contributions

N.B.M. supported in planning, data collection, statistical analysis, interpretation of results, literature survey, writing the manuscript, and submission. P.A., R.K., E.T.Y., and O.K.A. performed planning, data collection, and literature survey


Ethics Committee Approval

Kirikkale University Faculty of Medicine Local Ethics Committee (date: March 23, 2009, number: 2009/028).


Informed Consent

The polyp tissues were obtained retrospectively. Therefore, no informed consent were obtained.




Publication History

Received: 26 September 2019

Accepted: 11 June 2020

Article published online:
05 October 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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