STW 5 affects murine motility of distal colon

Background Colonic dysmotility is a hallmark pathophysiology in many functional and organic bowel disorders. Functional constipation is often one of the symptoms in bowel disorders, that by the presence of abdominal pain or discomfort, is responsible for a low quality of life. STW 5 (Iberogast®) is an herbal medicinal product with a proven clinical efficacy in functional gastrointestinal disorders including functional dyspepsia and irritable bowel syndrome.

Aim This study aims to evaluate the effect of STW 5 on colonic motility and to analyze region specific effects of the proximal and distal part of the murine colon.

Methods An ex vivo luminal perfusion setup has been used to investigate the impact of STW 5 on the healthy murine gut. Recorded motility patterns during perfusion were analyzed by mean interval and alterations of gut amplitude and finally converted into a heatmap.

Results Application of STW 5 in the healthy gut resulted in an activation of colonic motility. Moreover, we found a shortened mean interval and a decrease of gut diameter during

perfusion with Iberogast® . Velocity studies revealed a decreased distal motility in comparison to the proximal part of the murine colon, which suggests a calming effect of STW 5 on the distal part.

Conclusion Our findings confirm the functional impact of STW 5 on colon motility and support its proven clinical efficacy in bowel disorders as IBS and especially constipation.

Publikationsverlauf

Artikel online veröffentlicht:
08. September 2020