Abstract
In the past decades, a great number of stimuli-responsive systems have been developed
to be used as drug-delivery systems with high sensitivity and selectivity in targeted
therapy. Despite promising results, the current stimuli-responsive systems suffer
from the complexity of preparation, as most novel stimuli-responsive systems are based
on polymers. Small molecules have often been neglected as candidates for application
for stimuli-responsive systems. Recently, structures based on six-membered ring molecules
or bicyclic molecules have been developed into conformational switches working through
conformational interconversion. These single conformational switches have significantly
reduced the complexity of material preparation compared to polymers or copolymers.
In this review, we focus on ring-system-based conformational switches that are involved
in sensors and smart drug-delivery systems. We hope that this review will shed light
on ring-system-based single conformational switches for use in the development of
stimuli-responsive systems.
1 Introduction
2 Conformation Switches Based On Bispidine Derivatives
3 Conformation Switches Based On Cycloalkanes
4 Conformation Switches Based On Carbohydrates
5 Conclusion
Key words
stimuli-responsive systems - sensors - liposome drug delivery - ring systems - bispidine
derivatives - cyclohexanes - carbohydrates
