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DOI: 10.1055/s-0040-1721506
Prognostic Impact of Obstructive Sleep Apnea in Patients Presenting with Acute Symptomatic Pulmonary Embolism
Funding None.Abstract
Background In patients with pulmonary embolism (PE), there is a lack of comprehensive data on the prevalence and prognostic significance of pre-existing obstructive sleep apnea (OSA).
Methods In this study of patients with PE from the Registro Informatizado de la Enfermedad TromboEmbólica (RIETE) registry, we assessed the prevalence of OSA, and the association between pre-existing OSA and the outcomes of all-cause mortality, PE-related mortality, recurrences, and major bleeding over 30 days after initiation of PE treatment. Additionally, we also examined rates of outcomes within 90 days and 1 year following the diagnosis of PE.
Results Of 4,153 patients diagnosed with PE, 241 (5.8%; 95% confidence interval [CI]: 5.1–6.6%) had pre-existing OSA. Overall, 166 (4.0%; 95% CI: 3.4–4.6%) died during the first 30 days of follow-up. In multivariable analysis, the OSA syndrome was not a significant predictor of death from any cause (odds ratio [OR]: 1.5; 95% CI: 0.8–2.9; p = 0.19). However, patients with pre-existing OSA had an increased PE-specific mortality (adjusted OR: 3.0; 95% CI: 1.3–6.8; p = 0.01) compared with those without OSA. OSA was not significantly associated with 30-day recurrent venous thromboembolism (adjusted OR: 0.6; 95% CI: 0.1–4.7; p = 0.65) or major bleeds (adjusted OR: 1.0; 95% CI: 0.4–2.2; p = 1.0). Findings were similar at 90-day and 1-year follow-ups.
Conclusion In patients presenting with PE, pre-existing OSA is relatively infrequent. Patients with OSA were at increased risk of PE-related mortality when compared with those without OSA.
Authors' Contributions
Study concept and design: R.L.-M., D.J., B.B., and M.M. Acquisition of data, analysis and interpretation of data, and statistical analysis: R.L.-M., D.J., B.B. M.P.-A, A.G.-O, V.R., S.S., L.M., F.R.-C, and M.M. Critical revision of the manuscript for important intellectual content: R.L.-M., D.J., B.B. M.P.-A, A.G.-O, V.R., S.S., L.M., F.R.-C, and M.M. Study supervision: D.J. and M.M. The corresponding author, D.J., had full access to all the data in the study and had final responsibility for the decision to submit for publication.
* A full list of the RIETE investigators is given in [Supplementary Appendix A].
Publikationsverlauf
Eingereicht: 17. Juli 2020
Angenommen: 31. Oktober 2020
Artikel online veröffentlicht:
30. Dezember 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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