Neuropediatrics 2021; 52(05): 343-350
DOI: 10.1055/s-0040-1721703
Original Article

PredictMed: A Machine Learning Model for Identifying Risk Factors of Neuromuscular Hip Dysplasia: A Multicenter Descriptive Study

Carlo M. Bertoncelli
1   Department of Physical Therapy, Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, Florida, United States
2   E.E.A.P. H. Germain, Children Hospital, PredictMed Lab, Nice, France
,
Paola Altamura
3   Department of Medicinal Chemistry and Pharmaceutical Technology, University of Chieti, Chieti, Italy
,
Domenico Bertoncelli
4   Department of Information Engineering, Computer Science and Mathematics, University of L'Aquila, L'Aquila, Italy
,
Virginie Rampal
5   Department of Pediatric Orthopaedic Surgery, Lenval Children's University Hospital of Nice, Nice, France
,
Edgar Ramos Vieira
1   Department of Physical Therapy, Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, Florida, United States
,
Federico Solla
5   Department of Pediatric Orthopaedic Surgery, Lenval Children's University Hospital of Nice, Nice, France
› Author Affiliations
Funding None.

Abstract

Neuromuscular hip dysplasia (NHD) is a common and severe problem in patients with cerebral palsy (CP). Previous studies have so far identified only spasticity (SP) and high levels of Gross Motor Function Classification System as factors associated with NHD. The aim of this study is to develop a machine learning model to identify additional risk factors of NHD. This was a cross-sectional multicenter descriptive study of 102 teenagers with CP (60 males, 42 females; 60 inpatients, 42 outpatients; mean age 16.5 ± 1.2 years, range 12–18 years). Data on etiology, diagnosis, SP, epilepsy (E), clinical history, and functional assessments were collected between 2007 and 2017. Hip dysplasia was defined as femoral head lateral migration percentage > 33% on pelvic radiogram. A logistic regression-prediction model named PredictMed was developed to identify risk factors of NHD. Twenty-eight (27%) teenagers with CP had NHD, of which 18 (67%) had dislocated hips. Logistic regression model identified poor walking abilities (p < 0.001; odds ratio [OR] infinity; 95% confidence interval [CI] infinity), scoliosis (p = 0.01; OR 3.22; 95% CI 1.30–7.92), trunk muscles' tone disorder (p = 0.002; OR 4.81; 95% CI 1.75–13.25), SP (p = 0.006; OR 6.6; 95% CI 1.46–30.23), poor motor function (p = 0.02; OR 5.5; 95% CI 1.2–25.2), and E (p = 0.03; OR 2.6; standard error 0.44) as risk factors of NHD. The accuracy of the model was 77%. PredictMed identified trunk muscles' tone disorder, severe scoliosis, E, and SP as risk factors of NHD in teenagers with CP.

Supplementary Material



Publication History

Received: 27 May 2020

Accepted: 24 September 2020

Article published online:
22 December 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
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