Thorac Cardiovasc Surg
DOI: 10.1055/s-0040-1722692
Original Cardiovascular

Comparison of Self-Expanding RDV Perceval S versus TAVI ACURATE neo/TF

1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Victor Mauri*
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Elmar Kuhn
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Matti Adam
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Borko Ivanov
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Christian Frerker
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Tobias Schmidt
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Navid Mader
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Tanja Rudolph
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
3  Department of Cardiology/Angiology, Heart and Diabetes Center Bad Oeynhausen, Ruhr-University Bochum, Germany
,
Stephan Baldus
2  Department of Cardiology, Heart Center, University Hospital of Cologne, Cologne, Germany
,
Oliver Liakopoulos
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
4  Department of Cardiac Surgery, Campus Kerckhoff, University of Giessen, Germany
,
Thorsten Wahlers
1  Department of Cardiothoracic Surgery, Heart Center, University Hospital of Cologne, Cologne, Germany
› Author Affiliations
Funding None.

Abstract

Background Rapid deployment aortic valve replacement (RDAVR) and transcatheter aortic valve implantation (TAVI) have emerged as increasingly used alternatives to conventional aortic valve replacement to treat patients at higher surgical risk. Therefore, in this single-center study, we retrospectively compared clinical outcomes and hemodynamic performance of two self-expanding biological prostheses, the sutureless and rapid deployment valve (RDV) Perceval-S (PER) and the transcatheter heart valve (THV) ACURATE neo/TF (NEO) in a 1:1 propensity-score-matching (PSM) patient cohort.

Methods A total of 332 consecutive patients with symptomatic aortic valve stenosis underwent either singular RDAVR with PER (119) or TAVI with NEO (213) at our institutions between 2012 and 2017. To compare the unequal patient groups, a 1:1 PSM for preoperative data and comorbidities was conducted. Afterward, 59 patient pairs were compared with regard to relevant hemodynamic parameter, relevant paravalvular leak (PVL), permanent postoperative pacemaker (PPM) implantation rate, and clinical postoperative outcomes.

Results Postoperative clinical short-term outcomes presented with slightly higher rates for 30-day all-cause mortality (PER = 5.1% vs. NEO = 1.7%, p = 0.619) and major adverse cardiocerebral event in PER due to cerebrovascular events (transient ischemic attack [TIA]-PER = 3.4% vs. TIA-NEO = 1.7%, p = 0.496 and Stroke-PER = 1.7% vs. Stroke-NEO = 0.0%, p = 1). Moreover, we show comparable PPM rates (PER = 10.2% vs. NEO = 8.5%, p = 0.752). However, higher numbers of PVL (mild—PER = 0.0% vs. NEO = 55.9%, p = 0.001; moderate or higher—PER = 0.0% vs. NEO = 6.8%, p = 0.119) after TAVI with NEO were observed.

Conclusion Both self-expanding bioprostheses, the RDV-PER and THV-NEO provide a feasible option in elderly and patients with elevated perioperative risk. However, the discussed PER collective showed more postoperative short-term complications with regard to 30-day all-cause mortality and cerebrovascular events, whereas the NEO showed higher rates of PVL.

Authors' Contribution

S.G. and V.M. contributed to study design, data collection, data analysis and interpretation, and writing of the manuscript; both authors contributed equally to this work. E.K., M.A., K.E., and T.R. contributed to data collection and data analysis/interpretation. I. D., B.I., and C.G. contributed to collection of data and literature search. C.F., T.S., and N.M. contributed to data analysis and interpretation. S.B., O.L., and T. W. contributed to data analysis and interpretation, review, and correction of the manuscript.


* Both authors contributed equally to this work.




Publication History

Received: 13 September 2020

Accepted: 25 November 2020

Publication Date:
24 March 2021 (online)

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